BZ1 | BPTF inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $65.00 | ||
| 25 mg | $250.00 |
BZ1 (2766623-38-3) is a potent (Kd = 6.3 nM; IC50 = 67 nM BPTF Alphascreen) inhibitor of the bromodomain PHD finger transcription factor (BPTF). It displays >350-fold selectivity over BET bromodomains. BZ1 sensitized 4T1 mouse breast cancer cells to doxorubicin treatment. BPTF inhibition represents a potential strategy for the inhibition of nucleosome remodeling factor (NURF) and exploration of its function.
References/Citations:
- Zahid et al. (2021), New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition; J. Med. Chem. 64 13902
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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BZ1 (2766623-38-3) is a potent (Kd = 6.3 nM; IC50 = 67 nM BPTF Alphascreen) inhibitor of the bromodomain PHD finger transcription factor (BPTF). It displays >350-fold selectivity over BET bromodomains. BZ1 sensitized 4T1 mouse breast cancer cells to doxorubicin treatment. BPTF inhibition represents a potential strategy for the inhibition of nucleosome remodeling factor (NURF) and exploration of its function.
References/Citations:
- Zahid et al. (2021), New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition; J. Med. Chem. 64 13902
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