Size: | Price | Quantity | |
---|---|---|---|
10 mg | $35.00 | ||
50 mg | $160.00 |
C-176 (314054-00-7) is an inhibitor of the signaling molecule STING in mouse cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. Treatment of Trex-/- mice with C-176 resulted in a significant reduction in serum levels of Type I Interferons and amelioration of systemic inflammation.
References/Citations:
1)Haag et al. (2018), Targeting STING with covalent small-molecule inhibitors; Nature 559 269
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C-176 (314054-00-7) is an inhibitor of the signaling molecule STING in mouse cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. Treatment of Trex-/- mice with C-176 resulted in a significant reduction in serum levels of Type I Interferons and amelioration of systemic inflammation.
References/Citations:
1)Haag et al. (2018), Targeting STING with covalent small-molecule inhibitors; Nature 559 269
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