C22 Ceramide | MCSR inhibitor

CAS:
869501-30-4
Catalog Number:
10-1615
Activity:
MCSR inhibitor
Molecular Weight:
622.06
Molecular Formula:
C40H79NO3
Solubility:
Soluble in DMSO (up to 12 mg/ml with warming) or in Ethanol (up to 10 mg/ml with warming
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
2 mg$55.00
5 mg$130.00

C22 Ceramide (86950-30-14) is a long-chain ceramide containing behenic acid. Mitochondrial-to-cytosolic stress response (MCSR) is a recently identified stress response which can be induced by increased synthesis of fatty acids. C22-ceramide is an endogenous signaling lipid which specifically inhibits MCSR with no effect on unfolded protein responses within the mitochondria.1 Hearts overexpressing Acyl CoA synthetase1 contain elevated levels of C22-ceramide.2

References/Citations:

1) Kim et al. (2016), Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response; Cell, 166 1539
2) Goldenberg et al. (2016), Acyl-CoA synthase-1 links facilitated long chain fatty acid uptake to intracellular metabolic trafficking differently in hearts of male vs. female mice; J. Mol. Cell. Cardiol., 94 1

CAS:
869501-30-4
Catalog Number:
10-1615
Activity:
MCSR inhibitor
Molecular Weight:
622.06
Molecular Formula:
C40H79NO3
Solubility:
Soluble in DMSO (up to 12 mg/ml with warming) or in Ethanol (up to 10 mg/ml with warming
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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