C22 Ceramide | MCSR inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 2 mg | $55.00 | ||
| 5 mg | $130.00 |
C22 Ceramide (86950-30-14) is a long-chain ceramide containing behenic acid. Mitochondrial-to-cytosolic stress response (MCSR) is a recently identified stress response which can be induced by increased synthesis of fatty acids. C22-ceramide is an endogenous signaling lipid which specifically inhibits MCSR with no effect on unfolded protein responses within the mitochondria.1 Hearts overexpressing Acyl CoA synthetase1 contain elevated levels of C22-ceramide.2
References/Citations:
1) Kim et al. (2016), Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response; Cell, 166 1539
2) Goldenberg et al. (2016), Acyl-CoA synthase-1 links facilitated long chain fatty acid uptake to intracellular metabolic trafficking differently in hearts of male vs. female mice; J. Mol. Cell. Cardiol., 94 1
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
C22 Ceramide (86950-30-14) is a long-chain ceramide containing behenic acid. Mitochondrial-to-cytosolic stress response (MCSR) is a recently identified stress response which can be induced by increased synthesis of fatty acids. C22-ceramide is an endogenous signaling lipid which specifically inhibits MCSR with no effect on unfolded protein responses within the mitochondria.1 Hearts overexpressing Acyl CoA synthetase1 contain elevated levels of C22-ceramide.2
References/Citations:
1) Kim et al. (2016), Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response; Cell, 166 1539
2) Goldenberg et al. (2016), Acyl-CoA synthase-1 links facilitated long chain fatty acid uptake to intracellular metabolic trafficking differently in hearts of male vs. female mice; J. Mol. Cell. Cardiol., 94 1
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