C8-Ceramide | Protein kinase activator
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $200.00 |
C8-ceramide (74713-59-0) is a cell permeable ceramide analog. Stimulates ceramide-activated protein kinase.1 Induces apoptosis.2 Reported to inhibit apoptosis and gap junction intercellular communication (GJIC) in rat liver epithelial cells.3 C8-ceramide induces the secretion of brain-derived neurotrophic factor (BDNF) from microglia in vitro.4
References/Citations:
1) Mathias et al. (1991) Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha; Proc. Natl. Acad. Sci. USA, 88 109
2) Jarvis et al. (1993) Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway; Proc. Natl. Acad. Sci. USA 91 73
3) Upham et al. (2003), Differential roles of 2,6 and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis; Cancer Lett., 191 27
4) Nakajima et al. (2002), Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro; J. Neurochem., 80 697
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
C8-ceramide (74713-59-0) is a cell permeable ceramide analog. Stimulates ceramide-activated protein kinase.1 Induces apoptosis.2 Reported to inhibit apoptosis and gap junction intercellular communication (GJIC) in rat liver epithelial cells.3 C8-ceramide induces the secretion of brain-derived neurotrophic factor (BDNF) from microglia in vitro.4
References/Citations:
1) Mathias et al. (1991) Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha; Proc. Natl. Acad. Sci. USA, 88 109
2) Jarvis et al. (1993) Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway; Proc. Natl. Acad. Sci. USA 91 73
3) Upham et al. (2003), Differential roles of 2,6 and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis; Cancer Lett., 191 27
4) Nakajima et al. (2002), Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro; J. Neurochem., 80 697
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