CaCCInh-A01 | TMEM16A inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $180.00 |
CaCCInh-A01 (407587-33-1) is a potent inhibitor of TMEM16A (IC50 = 2.1 mM), a calcium-activated chloride channel1. Blockade of TMEM16A with CaCCInh-A01 protects against renal fibrosis2, reduces blood brain barrier permeability, attenuates brain infarct size and neurological deficits after ischemic stroke3, and induces apoptosis and cell cycle arrest in various epithelium-originated cancer cells4.
References/Citations:
- Namkung et al. (2011) TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells; J. Biol. Chem. 286 2365
- Li et al. (2022) Blockade of TMEM16A protects against renal fibrosis by reducing intracellular Cl– concentration; Br. J. Pharmacol. 179 3043
- Liu et al. (2019) TMEM16A Inhibition Preserves Blood-Brain Barrier Integrity After Ischemic Stroke; Front. Cell Neurosci. 13 360
- Guan et al. (2016) Inhibition of calcium-activated chloride channel ANO1 suppresses proliferation and induces apoptosis of epithelium originated cancer cells; Oncotarget 7 78619
C18H21NO4S
>98% TLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
CaCCInh-A01 (407587-33-1) is a potent inhibitor of TMEM16A (IC50 = 2.1 mM), a calcium-activated chloride channel1. Blockade of TMEM16A with CaCCInh-A01 protects against renal fibrosis2, reduces blood brain barrier permeability, attenuates brain infarct size and neurological deficits after ischemic stroke3, and induces apoptosis and cell cycle arrest in various epithelium-originated cancer cells4.
References/Citations:
- Namkung et al. (2011) TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells; J. Biol. Chem. 286 2365
- Li et al. (2022) Blockade of TMEM16A protects against renal fibrosis by reducing intracellular Cl– concentration; Br. J. Pharmacol. 179 3043
- Liu et al. (2019) TMEM16A Inhibition Preserves Blood-Brain Barrier Integrity After Ischemic Stroke; Front. Cell Neurosci. 13 360
- Guan et al. (2016) Inhibition of calcium-activated chloride channel ANO1 suppresses proliferation and induces apoptosis of epithelium originated cancer cells; Oncotarget 7 78619
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