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Caerulomycin A | Blocks STAT1 signaling / Immunosuppressant

Caerulomycin A (21802-37-9) chemically novel and potent immunosuppressive agent. Suppresses T cell activation and IFN7gamma; secretion in vitro and in vivo1. Caerulomycin A induces expansion of regulatory T cells by via interfering with IFNγ -induced STAT1 signaling2.

References/Citations
1) Singla et al. (2014), Caerulomycin A suppresses immunity by inhibiting T cell activity; PLoS One, 9(10) e107051
2) Gurram et al. (2014), Caerulomycin A enhances transforming growth factor-beta (TGF-β)-Smad3 protein signaling by suppressing interferon-gamma (IFN-γ)-signaling to expand regulatory T cells (Tregs); J. Biol. Chem. 289 17515

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Catalog#  10-2897

$80.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
21802-37-9
Catalog Number:
10-2897
Activity:
Blocks STAT1 signaling / Immunosuppressant
Chemical Name:
(2Z)-4-Methoxy-2-(nitrosomethylidene)-6-pyridin-2-yl-1H-pyridine
Molecular Weight:
229.23
Molecular Formula:
C12H11N3O2
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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