Caerulomycin A (21802-37-9) chemically novel and potent immunosuppressive agent. Suppresses T cell activation and IFN7gamma; secretion in vitro and in vivo1. Caerulomycin A induces expansion of regulatory T cells by via interfering with IFNγ -induced STAT1 signaling2.
1) Singla et al. (2014), Caerulomycin A suppresses immunity by inhibiting T cell activity; PLoS One, 9(10) e107051
2) Gurram et al. (2014), Caerulomycin A enhances transforming growth factor-beta (TGF-β)-Smad3 protein signaling by suppressing interferon-gamma (IFN-γ)-signaling to expand regulatory T cells (Tregs); J. Biol. Chem. 289 17515