Calphostin C | Protein kinase C inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 100 µg | $138.00 | ||
| 500 µg | $670.00 |
Calphostin C (121263-19-2) is a potent and specific inhibitor of protein kinase C (PKC, IC50 = 50 nM).1 Inhibition of PKC is light dependent2 and is competitive with the diacylglycerol / phorbol ester binding site1. Calphostin C competes with the diacylglycerol / phorbol ester binding site in other proteins such as Munc13-1.3 Reverses oxycodone-induced tolerance to respiratory depression.4
References/Citations:
- Kobayashi et al. (1989), Calphostin C (UNC-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C; Biochem. Biophys. Res. Commun. 159 548
- Bruns et al. (1991), Inhibition of protein kinase C by calphostin C is light-dependent; Biochem. Biophys. Res. Commun. 176 288
- Betz et al. (1998), Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release; Neuron 21 123
- Hill et al. (2018), Oxycodone-induced tolerance to respiratory depression: reversal by ethanol, pregabalin and protein kinase C inhibition; Br. J. Pharmacol. 175 2492
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Calphostin C (121263-19-2) is a potent and specific inhibitor of protein kinase C (PKC, IC50 = 50 nM).1 Inhibition of PKC is light dependent2 and is competitive with the diacylglycerol / phorbol ester binding site1. Calphostin C competes with the diacylglycerol / phorbol ester binding site in other proteins such as Munc13-1.3 Reverses oxycodone-induced tolerance to respiratory depression.4
References/Citations:
- Kobayashi et al. (1989), Calphostin C (UNC-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C; Biochem. Biophys. Res. Commun. 159 548
- Bruns et al. (1991), Inhibition of protein kinase C by calphostin C is light-dependent; Biochem. Biophys. Res. Commun. 176 288
- Betz et al. (1998), Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release; Neuron 21 123
- Hill et al. (2018), Oxycodone-induced tolerance to respiratory depression: reversal by ethanol, pregabalin and protein kinase C inhibition; Br. J. Pharmacol. 175 2492
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