5-Fluorouracil | Inhibitor of thymidylate synthase

CAS:
51-21-8
Catalog Number:
10-1276
Activity:
Inhibitor of thymidylate synthase
Alternate Names:
5-FU
Chemical Name:
5-Fluoro-1H,3H-pyrimidine-2,4-dione
Molecular Weight:
130.08
Molecular Formula:
C4H3FN2O2
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98%
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Available Options

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250 mg$20.00
1 gram$30.00
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5-Fluorouracil (51-21-8) is a clinically useful anticancer agent that acts via irreversible inhibition of thymidylate synthase. The active metabolites of 5-Fluorouracil are 5-Fluorodeoxyuridylate (5-FdUMP), 5-Fluorodeoxyuridine triphosphate (5-FdUTP) and 5-Fluorouridine triphosphate (5-FUTP). The primary cytotoxic effect of 5-Fluorouracil is believed to be inhibition of thymidylate synthase by 5-FdUMP. Secondary effects include incorporation of 5-FdUTP into DNA resulting in DNA strand breaks and incorporation of 5-FUTP into RNA causing abnormal RNA processing.1

References/Citations:

1) Schlisky (1998), Biochemical and Clinical Pharmacology of 5-Fluorouracil; Oncology, 12 13

CAS:
51-21-8
Catalog Number:
10-1276
Activity:
Inhibitor of thymidylate synthase
Alternate Names:
5-FU
Chemical Name:
5-Fluoro-1H,3H-pyrimidine-2,4-dione
Molecular Weight:
130.08
Molecular Formula:
C4H3FN2O2
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98%
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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