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Cantharidin | Phosphatase PP2A inhibitor

Cantharidin (56-25-7) inhibits protein phosphatase 2A (Ki=0.19 μM) and PP1 (Ki=1.1 μM)1. Displays >500-fold selectivity over PP2B. Suppresses growth and migration of PANC-1 pancreatic cancer cells via phosphorylation and degradation of β-catenin2. Cantharidin arrests G2/M transition via JNK/Sp1-dependent down-regulation of CDK13. Cell permeable.
Warning: Avoid skin contact, may cause skin irritation or blistering.

References/Citations
1) Honkanen (1993) Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A; FEBS Lett. 330 283
2) Wu et al. (2014) PP2A inhibitors suppress migration and growth of PANC-1 pancreatic cancer cells through inhibition on the Wnt/β-Catenin pathway by phosphorylation and degradation of β-catenin; Oncol. Rep., 32 513
3) Gong et al. (2015) PP2A inhibitors arrest G2/M transition through JNK/Sp1-dependent down-regulation of CDK1 and autophagy up-regulation of p21; Oncotarget, 6 18469

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Cantharidin | 56-25-7 | Structure | Supplier

Catalog#  10-1013

$40.00
Quantity
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CAS:
56-25-7
Catalog Number:
10-1013
Activity:
Phosphatase PP2A inhibitor
Chemical Name:
3α,7α-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione
Molecular Weight:
196.2
Molecular Formula:
C10H12O4
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 weeks.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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