Carboxy-PTIO Potassium Salt | Nitric oxide scavenger

CAS:
148819-94-7
Catalog Number:
10-3037
Activity:
Nitric oxide scavenger
Chemical Names:

2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, potassium salt

Molecular Weight:
315.39
Molecular Formula:
C14H16KN2O4
Solubility:
Soluble in Water (up to 100 mg/ml) or in DMSO (up to 50 mg/ml)
Physical Properties:
Blue solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
50 mg$190.00
10 mg$50.00

A nitric oxide (NO) scavenger.  Carboxy-PTIO (148819-94-7) reacts with NO with 1:1 stoichiometry1 producing NO2/NO3.   In LPS-induced endotoxin shock, carboxy-PTIO reversed hypotension and renal dysfunction and increased survival in a rat model.2 A very useful tool for probing the involvement of NO in physiological processes.3,4

References:

  1. Akaike et al. (1993), Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction, Biochemistry, 32 827
  2. Yoshida et al. (1994), Therapeutic effects of imidazolineoxyl N-oxide against endotoxin shock through its direct nitric oxide-scavenging activity; Biochem. Biophys. Res. Commun., 202 923
  3. Hada et al. (2019), Nitric Oxide Is Involved in Heavy Ion-Induced Non-Targeted Effects in Human Fibroblasts; Int. J. Mol. Sci., 20 4327
  4. Jin et al. (2020), A novel quinolinylmethyl substituted ethylenediamine compound exerts anti-cancer effects via stimulating the accumulation of reactive oxygen species and NO in hepatocellular carcinoma cells; Eur. J. Pharmacol., 885 173497
CAS:
148819-94-7
Catalog Number:
10-3037
Activity:
Nitric oxide scavenger
Chemical Names:

2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, potassium salt

Molecular Weight:
315.39
Molecular Formula:
C14H16KN2O4
Solubility:
Soluble in Water (up to 100 mg/ml) or in DMSO (up to 50 mg/ml)
Physical Properties:
Blue solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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