Norfluoxetine HCl | Fluoxetine Metabolite
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $200.00 |
Norfluoxetine HCl (57226-68-3) is a metabolite of fluoxetine.3 Induces long QT syndrome via slow delayed rectifier potassium current block.1 Time dependent inhibitor of CYP2C19 and CYP3A4.2 The S-isomer of desmethylfluoxetine is the active N-demethylated metabolite responsible for the persistently potent and selective inhibition of serotonin uptake in vivo.3 Potent inhibitor of coxsackievirus replication acting via inhibition of viral RNA synthesis.4 State-dependent TREK-2 blocker.5
References/Citations:
1) Veerman et al. (2013), Slow delayed rectifier potassium current blockade contributes importantly to drug-induced long QT syndrome; Circ. Arrythm. Electrophysiol. 6 1002
2) Lutz et al. (2013), Stereoselective inhibition of CYP2C1 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems; Drug Metab. Dispos. 41 2056
3) Wong et al. (1993), Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain; Neuropsychopharmacology 8 337
4) Zuo et al. (2012), Fluoxetine is a potent inhibitor of coxsackievirus replication.; Antimicrob. Agents Chemother. 56 4838
5) McClenaghan et al. (2016), Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states; J. Gen. Physiol. 147 497
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Norfluoxetine HCl (57226-68-3) is a metabolite of fluoxetine.3 Induces long QT syndrome via slow delayed rectifier potassium current block.1 Time dependent inhibitor of CYP2C19 and CYP3A4.2 The S-isomer of desmethylfluoxetine is the active N-demethylated metabolite responsible for the persistently potent and selective inhibition of serotonin uptake in vivo.3 Potent inhibitor of coxsackievirus replication acting via inhibition of viral RNA synthesis.4 State-dependent TREK-2 blocker.5
References/Citations:
1) Veerman et al. (2013), Slow delayed rectifier potassium current blockade contributes importantly to drug-induced long QT syndrome; Circ. Arrythm. Electrophysiol. 6 1002
2) Lutz et al. (2013), Stereoselective inhibition of CYP2C1 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems; Drug Metab. Dispos. 41 2056
3) Wong et al. (1993), Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain; Neuropsychopharmacology 8 337
4) Zuo et al. (2012), Fluoxetine is a potent inhibitor of coxsackievirus replication.; Antimicrob. Agents Chemother. 56 4838
5) McClenaghan et al. (2016), Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states; J. Gen. Physiol. 147 497
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