CBD3063 | Cav2.2 blocker
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $80.00 | ||
| 25 mg | $285.00 |
CBD3063 (1281060-70-5) is a first-in-class modulator of the Cav2.2 channel that disrupts Cav2.2 interaction with the cytosolic auxiliary subunit collapsing response mediator protein 2 (CRMP2). CBD3063 antagonizes Cav2.2 function and blocks neuropathic and inflammatory pain in mouse models. In contrast to gabapentin (a clinically useful Cav2.2 blocker), CBD3063 did not affect somatosensation and did not compromise the protective role of pain in mice. CBD3063 did not induce sedative, affective, or cognitive effects in mice. It also induced anxiolytic-like effects suggesting partial blood-brain barrier penetration. CDB3063 represents a potential new and superior therapeutic agent for chronic pain.
References/Citations:
- Gomez et al. (2023), A peptidomimetic modulator of the Cav2.2 N-type calcium channel for chronic pain; Proc. Natl. Acad. Sci. USA 120 e2305215120
C16H25N5O2
>98% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
CBD3063 (1281060-70-5) is a first-in-class modulator of the Cav2.2 channel that disrupts Cav2.2 interaction with the cytosolic auxiliary subunit collapsing response mediator protein 2 (CRMP2). CBD3063 antagonizes Cav2.2 function and blocks neuropathic and inflammatory pain in mouse models. In contrast to gabapentin (a clinically useful Cav2.2 blocker), CBD3063 did not affect somatosensation and did not compromise the protective role of pain in mice. CBD3063 did not induce sedative, affective, or cognitive effects in mice. It also induced anxiolytic-like effects suggesting partial blood-brain barrier penetration. CDB3063 represents a potential new and superior therapeutic agent for chronic pain.
References/Citations:
- Gomez et al. (2023), A peptidomimetic modulator of the Cav2.2 N-type calcium channel for chronic pain; Proc. Natl. Acad. Sci. USA 120 e2305215120
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