CBR-470-1 | NRF2 signaling activator

CAS:
 2416095-06-0
Catalog Number:
 10-4680
CBR-470-1 Supplier | CAS 2416095-06-0 | Focus Biomolecules

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25mg$225.00
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CBR-470-1 (2416095-06-0) is an activator of NRF2 signaling (EC50 ~ 1 µM cellular ARE-LUC assay).1 It inhibits phosphoglycerate kinase 1 leading to a build-up of methylglyoxal which inactivates KEAP1. It protected SH-SY5Y neuronal cells from MPP+ induced oxidative injury via activation of NRF2 signaling.2

References/Citations:

  1. Bollong et al. (2018) A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling; Nature 562 600
  2. Zheng et al. (2020) PGK1 inhibitor CBR-470-1 protects neuronal cells from MPP+; Aging (Albany NY) 12 13388
CAS:
2416095-06-0
Catalog Number:
10-4680
Activity:
NRF2 activator
Chemical Names:
trans-4-(4-Chlorophenyl)sulfonyl-N-(2-methylpropyl)-1,1-dioxothiolan-3-amine
Molecular Weight:
365.89
Molecular Formula:

C14H20ClNO4S2

Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:

>98% HPLC
NMR (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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