Ceapin-A7 | ATF6α/UPR inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $75.00 | ||
| 50 mg | $295.00 |
Ceapin-A7 (2323027-38-7) is a selective inhibitor (IC50 = 590 nM) of transcription factor ATF6α, one of the three branches of the unfolded protein response.1 It inhibits activation of ATF6α in response to ER stress without inhibiting ER-bound transcription factors ATF6ß or SREBP or the IRE1 or PERK branches of the UPR. Ceapin-A7 also show no toxicity to unstressed cells. It induces neomorphic association of the ER and peroxisomes by directly tethering the cytosolic domain of ATF6a to the peroxisomal transporter ABCD3 without inhibiting its transporter activity.2 See companion activator 10-3973.
References/Citations:
- Gallagher et al. (2016), Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch; eLife 5 e11878
- Torres et al. (2019), Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether; eLife 8 e46595
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Ceapin-A7 (2323027-38-7) is a selective inhibitor (IC50 = 590 nM) of transcription factor ATF6α, one of the three branches of the unfolded protein response.1 It inhibits activation of ATF6α in response to ER stress without inhibiting ER-bound transcription factors ATF6ß or SREBP or the IRE1 or PERK branches of the UPR. Ceapin-A7 also show no toxicity to unstressed cells. It induces neomorphic association of the ER and peroxisomes by directly tethering the cytosolic domain of ATF6a to the peroxisomal transporter ABCD3 without inhibiting its transporter activity.2 See companion activator 10-3973.
References/Citations:
- Gallagher et al. (2016), Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch; eLife 5 e11878
- Torres et al. (2019), Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether; eLife 8 e46595
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