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IOX 1 | JMJD demethylase inhibitor

IOX 1 (5852-78-8) inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively.1 A broad spectrum 2-oxoglutarate oxygenase inhibitor, IOX 1 may be used to study hypoxic signaling.1 Cell permeable

References/Citations:

1) King et al. (2010), Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors; PLoS One, 5 e15535

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
size :

5 mg, 25 mg

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CAS:
5852-78-8
Catalog Number:
10-1426
Activity:
JMJD demethylase inhibitor
Alternate Names:
5-Carboxy-8HQ
Chemical Name:
8-Hydroxy-5-quinolinecarboxylic acid
Molecular Weight:
189.17
Molecular Formula:
C10H7NO3
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

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IOX 1 | JMJD demethylase inhibitor

$72.00 – $288.00

CAS:
5852-78-8
Catalog Number:
10-1426
Activity:
JMJD demethylase inhibitor
Alternate Names:
5-Carboxy-8HQ
Chemical Name:
8-Hydroxy-5-quinolinecarboxylic acid
Molecular Weight:
189.17
Molecular Formula:
C10H7NO3
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
  • 5 mg
  • 25 mg
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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Home >> Products >> IOX 1 | JMJD demethylase inhibitor

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