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TC-E 5003 | Arginine methyltransferase 1 (PRMT1) inhibitor

TC-E 5003 (17328-16-4) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor, IC50 = 1.5 μM. Displays no activity against CARM1 and Set7/9 methyltransferases. TC-E 5003 inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells. Blocks androgen-induced gene expression in LNCaP cells1.

References/Citations
1) Bissinger et al. (2011), Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methytransferase hPRMT1; Bioorg. Med. Chem., 19 3717

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Focus Biomolecules supplier, structure of TC-E 5033 | Arginine methyltransferase 1 (PRMT1) inhibitor | CAS 17328-16-4

Catalog#  10-1499

$60.00
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CAS:
17328-16-4
Catalog Number:
10-1499
Activity:
Arginine methyl transferase 1 (PRMT1) inhibitor
Chemical Name:
N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide)
Molecular Weight:
401.26
Molecular Formula:
C16H14Cl2N2O4S
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Brown solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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