L-Buthionine Sulfoximine | GCL inhibitor

L-Buthionine sulfoximine (83730-53-4) is an irreversible inhibitor of γ-glutamylcysteine ligase (GCL). GCL is the first enzyme of the cellular glutathione biosynthetic pathway. Dysregulation of glutathione homeostasis is involved in many diseases including cancer, diabetes, neurodegenerative disorders and HIV/AIDS.1 Most disease states involve decreased glutathione synthesis, however, in cancer, it is increased supporting cellular proliferation and protecting cancer cells. Pharmacological inhibition of GCL has been examined as a potential cancer treatment.2-4

References/Citations
1) Lu et al. (2009), Regulation of glutathione synthesis; Mol. Aspects Med. 30 42
2) Lee et al. (2008), Adaptive response to GSH depletion and resistance to L-buthionine-(S,R)-sulfoximine; Mol. Cell Biochem. 12 174
3) Qiwei et al. (2016), The effects of buthionine sulfoximine on the proliferation and apoptosis of biliary tract cancer cells induced by cisplatin and gemcitabine; Oncol. Lett. 11 474
4) Glasuer and Chandel (2014), Targeting antioxidants for cancer therapy; Biochem. Pharmacol. 92 90

Weight 1 mg
Dimensions 1 × 1 × 1 cm
Size;

100 mg, 250 mg

Reviews

There are no reviews yet.

Be the first to review “L-Buthionine Sulfoximine | GCL inhibitor”

Your email address will not be published. Required fields are marked *

Product Inquiry

CAS:
83730-53-4
Catalog Number:
10-4572
Activity:
GCL inhibitor
Chemical Name:
2(S)-Amino-4-(S-butylsulfonimidoyl)butanoic acid
Molecular Weight:
222.31
Molecular Formula:
C8H18N2O3S
Solubility:
Soluble in Water (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions are not stable and must be prepared fresh daily.
Shipping Code:
RT

L-Buthionine Sulfoximine | GCL inhibitor

$50.00$90.00

CAS:
83730-53-4
Catalog Number:
10-4572
Activity:
GCL inhibitor
Chemical Name:
2(S)-Amino-4-(S-butylsulfonimidoyl)butanoic acid
Molecular Weight:
222.31
Molecular Formula:
C8H18N2O3S
Solubility:
Soluble in Water (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions are not stable and must be prepared fresh daily.
Shipping Code:
RT
  • 100 mg
  • 250 mg
Clear
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.