CEP | Protein-RNA binding click probe
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $80.00 | ||
| 25 mg | $320.00 |
CEP (1838570-66-3) is a clickable electrophilic purine which may be used to directly quantify protein-RNA interaction on proteins via photoaffinity competition with 4-thiouridine-labeled RNA in cells. Employing CEP in a photo-activatable-competition and chemoproteomic enrichment (PACCE) protocol enables functional profiling of canonical RNA-binding domains as well as the discovery of “moonlighting” RNA binding activity in the human proteome. This new methodology represents a chemoproteomic platform for global quantification of protein-RNA binding activity in living cells.
References/Citations:
- Heindel et al. (2023), Chemoproteomic capture of RNA binding activity in living cells; Nat. Commun. 14 6282
C8H4Cl2N4
>98% TLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
CEP (1838570-66-3) is a clickable electrophilic purine which may be used to directly quantify protein-RNA interaction on proteins via photoaffinity competition with 4-thiouridine-labeled RNA in cells. Employing CEP in a photo-activatable-competition and chemoproteomic enrichment (PACCE) protocol enables functional profiling of canonical RNA-binding domains as well as the discovery of “moonlighting” RNA binding activity in the human proteome. This new methodology represents a chemoproteomic platform for global quantification of protein-RNA binding activity in living cells.
References/Citations:
- Heindel et al. (2023), Chemoproteomic capture of RNA binding activity in living cells; Nat. Commun. 14 6282
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