Cepharanthine | Autophagy inhibitor/Antiviral
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 50 mg | $35.00 | ||
| 250 mg | $140.00 |
Cepharanthine (481-49-2) is a naturally occurring alkaloid from Stephania cepharantha Hayata which possesses a number of pharmacological activities.1 Attenuates LPS-induced expression of TNF-a, IL-6 and IL-1b in macrophages and inhibits NF-kB activation.2 Induces mitophagy possibly by acting at GPR30 in hepatocellular carcinoma.3 Inhibits autophagosome-lysosome fusion and autophagy by downregulation of MYO1C an actin-based motor protein.4 Potently inhibits replication of SARS CoV-2 and homologous viruses.5
References:
- Rogosnitzky and Dank (2011), Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions; Pharmacol. Rep., 63 337
- Huang et al. (2014), Cepharanthine, an alkaloid from Stephania cepharantha Hayata inhibits the inflammatory response in the RAW264.7 cell and mouse models; Inflammation, 37 235
- Wang et al. (2020), Cepharanthine hydrochloride induces mitophagy targeting GPR30 in hepatocellular carcinoma (HCC); Expert Opin. Ther. Targets, 24 389
- Zhang et al. (2019), Downregulation of MYO1C mediated by cepharanthine inhibits autophagosome-lysosome fusion through blockade of the F-actin network; J. Exp. Clin. Cancer Res. 38 457
- Rosognitzky et al. (2020), Cepharanthine: a review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19; Pharmacol. Rep., 72 1509
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Cepharanthine (481-49-2) is a naturally occurring alkaloid from Stephania cepharantha Hayata which possesses a number of pharmacological activities.1 Attenuates LPS-induced expression of TNF-a, IL-6 and IL-1b in macrophages and inhibits NF-kB activation.2 Induces mitophagy possibly by acting at GPR30 in hepatocellular carcinoma.3 Inhibits autophagosome-lysosome fusion and autophagy by downregulation of MYO1C an actin-based motor protein.4 Potently inhibits replication of SARS CoV-2 and homologous viruses.5
References:
- Rogosnitzky and Dank (2011), Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions; Pharmacol. Rep., 63 337
- Huang et al. (2014), Cepharanthine, an alkaloid from Stephania cepharantha Hayata inhibits the inflammatory response in the RAW264.7 cell and mouse models; Inflammation, 37 235
- Wang et al. (2020), Cepharanthine hydrochloride induces mitophagy targeting GPR30 in hepatocellular carcinoma (HCC); Expert Opin. Ther. Targets, 24 389
- Zhang et al. (2019), Downregulation of MYO1C mediated by cepharanthine inhibits autophagosome-lysosome fusion through blockade of the F-actin network; J. Exp. Clin. Cancer Res. 38 457
- Rosognitzky et al. (2020), Cepharanthine: a review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19; Pharmacol. Rep., 72 1509
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