Cercosporin | ROS-generating fungal toxin
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 1 mg | $60.00 | ||
| 5 mg | $240.00 |
Cercosporin (35082-49-6) is a perylenequinone from the fungus Cercospora kikuchii. Upon photo- activation, perylenequinones display almost universal toxicity to a broad variety of organisms.1 Exposure to visible and near-UV light activates this family of quinones to an excited triplet state that reacts with oxygen to form reactive oxygen species.2 Displays antiproliferative effects in various tumor cell lines.3 Selectively inhibits PKC (IC50=0.6-1.3 µM) over PKA and PPK.4
References/Citations:
- Daub et al. (2013), Reactive oxygen species in plant pathogenesis: the role of perylenequinone photosensitizers; Antioxid. Redox. Signal 19 970
- Guedes and Eriksson (2007), Photophysics, photochemistry, and reactivity: molecular aspects of perylenequinone reactions, Photochem. Photobiol. Sci. 6 1089
- Vandenbogaerde et al. (1998), Cytotoxicity and antiproliferative effect of hypericin and derivatives after photosensitization; Photochem. Photobiol., 67 119
- Morgan et al. (2009), Design, Synthesis, and Investigation of Protein Kinase C Inhibitors: Total Syntheses of (+)-Calphostin D, (+)-Phleichrome, Cercosporin, and New Photoactive Perylenequinones; J. Am. Chem. Soc., 131 9413
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Cercosporin (35082-49-6) is a perylenequinone from the fungus Cercospora kikuchii. Upon photo- activation, perylenequinones display almost universal toxicity to a broad variety of organisms.1 Exposure to visible and near-UV light activates this family of quinones to an excited triplet state that reacts with oxygen to form reactive oxygen species.2 Displays antiproliferative effects in various tumor cell lines.3 Selectively inhibits PKC (IC50=0.6-1.3 µM) over PKA and PPK.4
References/Citations:
- Daub et al. (2013), Reactive oxygen species in plant pathogenesis: the role of perylenequinone photosensitizers; Antioxid. Redox. Signal 19 970
- Guedes and Eriksson (2007), Photophysics, photochemistry, and reactivity: molecular aspects of perylenequinone reactions, Photochem. Photobiol. Sci. 6 1089
- Vandenbogaerde et al. (1998), Cytotoxicity and antiproliferative effect of hypericin and derivatives after photosensitization; Photochem. Photobiol., 67 119
- Morgan et al. (2009), Design, Synthesis, and Investigation of Protein Kinase C Inhibitors: Total Syntheses of (+)-Calphostin D, (+)-Phleichrome, Cercosporin, and New Photoactive Perylenequinones; J. Am. Chem. Soc., 131 9413
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