Cerulenin | Fatty acid synthase inhibitor
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $120.00 | ||
| 25 mg | $540.00 |
Cerulenin (17397-89-6) is a fatty acid synthase (FAS) inhibitor. Binds to β-keto-acyl-ACP synthase (KAS; IC50=1.5 μM), thus inhibiting protein acylation at concentrations of 45-134 μM.1 Cerulenin produces metabolic effects similar to the effects of leptin, but through mechanisms that are independent of, or down-stream of, both leptin and melanocortin receptors.2 Reduces nutrient-induced insulin release from normal rat islets.3 Induces apoptosis in human melanoma A-375 cells.4
References/Citations:
1) Yasuno et al. (2004), Identification and molecular characterization of the beta-ketoacyl-[acyl carrier protein] synthase component of the Arabidopsis mitochondrial fatty acid synthase; J. Biol. Chem., 279 8242
2) Makimura et al. (2001), Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting; Diabetes, 50 733
3) Metz et al. (1993), Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins; Biochem. J., 295 31
4) Ho et al. (2007), Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells; Biomed. Pharmacother., 61 578
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Cerulenin (17397-89-6) is a fatty acid synthase (FAS) inhibitor. Binds to β-keto-acyl-ACP synthase (KAS; IC50=1.5 μM), thus inhibiting protein acylation at concentrations of 45-134 μM.1 Cerulenin produces metabolic effects similar to the effects of leptin, but through mechanisms that are independent of, or down-stream of, both leptin and melanocortin receptors.2 Reduces nutrient-induced insulin release from normal rat islets.3 Induces apoptosis in human melanoma A-375 cells.4
References/Citations:
1) Yasuno et al. (2004), Identification and molecular characterization of the beta-ketoacyl-[acyl carrier protein] synthase component of the Arabidopsis mitochondrial fatty acid synthase; J. Biol. Chem., 279 8242
2) Makimura et al. (2001), Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting; Diabetes, 50 733
3) Metz et al. (1993), Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins; Biochem. J., 295 31
4) Ho et al. (2007), Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells; Biomed. Pharmacother., 61 578
Related products
-
JZL-184 | MAG lipase inhibitor
From $62.00CAS:1101854-58-3Catalog Number:10-1021Activity:MAG lipase inhibitorChemical Name:4-Nitrophenyl-4-(dibenzo[d][1,3]dioxol-5-yl(hydroxyl)methyl)piperidine-1-carboxylateMolecular Weight:520.5Molecular Formula:C27H24N2O9Solubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:Light yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 monthsShipping Code:RT -
MK-886 | FLAP inhibitor
From $70.00CAS:118414-82-7Catalog Number:10-1040Activity:FLAP inhibitorAlternate Names:L-663,536Chemical Name:3-[1-(4-Chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acidMolecular Weight:472.08Molecular Formula:C27H34ClNO2SSolubility:Soluble in DMSO (up to 40 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.Shipping Code:RT -
Zafirlukast | HSP70 inhibitor and leukotriene antagonist
From $28.00CAS:107753-78-6Catalog Number:10-1100Activity:Hsp70 inhibitorAlternate Names:ICI-204219Molecular Weight:575.69Molecular Formula:C31H33N3O6SSolubility:Soluble in DMSO (up to 10 mg/ml).Physical Properties:White or pink solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
20% OFF
For Postdoc
Customers!
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.