CFM-4 | CARP-1 mimetic

CAS:
331458-02-7
Catalog Number:
10-1493
Activity:
Carp-1 mimetic
Chemical Name:
1-[(2-Chlorophenyl)methyl]-5′-phenyl-spiro[3H-indole-3,2′(3’H)-[1,3,4]thiadiazol]-2(1H)-one
Molecular Weight:
405.90
Molecular Formula:
C22H16ClN3OS
Solubility:
Soluble in DMSO (greater than 25 mg/ml)
Physical Properties:
Tan solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$70.00
25 mg$280.00

CFM-4 (331458-02-7) is a CARP-1 functional mimetic that interferes with CARP-1 binding to APC-2 (IC50=10-15 μM).1 Enhances CARP-1 expression and induces G2/M cell cycle arrest. Induces apoptosis and suppresses growth of medulloblastoma cells2 and malignant pleural mesothelioma cells3.

References/Citations:

1) Puliyappadamba et al. (2011), Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis; J. Biol. Chem. 286 38000
2) Ashour et al. (2013), CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth; PLoS ONE 8 e66733
3) Jamal et al. (2014), CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells; PLoS ONE 9 e89146

CAS:
331458-02-7
Catalog Number:
10-1493
Activity:
Carp-1 mimetic
Chemical Name:
1-[(2-Chlorophenyl)methyl]-5′-phenyl-spiro[3H-indole-3,2′(3’H)-[1,3,4]thiadiazol]-2(1H)-one
Molecular Weight:
405.90
Molecular Formula:
C22H16ClN3OS
Solubility:
Soluble in DMSO (greater than 25 mg/ml)
Physical Properties:
Tan solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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