Size : | Price | Quantity | |
---|---|---|---|
5 mg | $70.00 | ||
25 mg | $280.00 |
CFM-4 (331458-02-7) is a CARP-1 functional mimetic that interferes with CARP-1 binding to APC-2 (IC50=10-15 μM).1 Enhances CARP-1 expression and induces G2/M cell cycle arrest. Induces apoptosis and suppresses growth of medulloblastoma cells2 and malignant pleural mesothelioma cells3.
References/Citations:
1) Puliyappadamba et al. (2011), Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis; J. Biol. Chem. 286 38000
2) Ashour et al. (2013), CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth; PLoS ONE 8 e66733
3) Jamal et al. (2014), CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells; PLoS ONE 9 e89146
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CFM-4 (331458-02-7) is a CARP-1 functional mimetic that interferes with CARP-1 binding to APC-2 (IC50=10-15 μM).1 Enhances CARP-1 expression and induces G2/M cell cycle arrest. Induces apoptosis and suppresses growth of medulloblastoma cells2 and malignant pleural mesothelioma cells3.
References/Citations:
1) Puliyappadamba et al. (2011), Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis; J. Biol. Chem. 286 38000
2) Ashour et al. (2013), CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth; PLoS ONE 8 e66733
3) Jamal et al. (2014), CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells; PLoS ONE 9 e89146
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