Chaetoglobosin A | Actin binding agent / Apoptosis inducer

CAS:
50335-03-0
Catalog Number:
10-3081
Activity:
Actin binding agent / Apoptosis inducer
Chemical Name:
(7S,13E, 16S, 17E, 19R, 21E)-6,7-Epoxy-19-hydroxy-10-(1H-indol-3-yl)-16,18-dimethyl-[13]cytochalasa- 13,17,21-triene-1,20,23-trione
Molecular Weight:
528.64
Molecular Formula:
C32H36N2O5
Solubility:
Soluble in DMSO (up to 5 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

SizePriceQuantity 
1 mg$100.00
5 mg$370.00

Chaetoglobosin A (50335-03-0) is a cytochalasin analog which targets filamentous actin. Displays cytotoxic effects against human colorectal HCT116 cells, IC50=3.15 μM.1 Preferentially induces apoptosis in chronic lymphocytic leukemia cells via targeting the cytoskeleton.2 Enhances the fibrinolytic activity of vascular endothelial cells.3

References/Citations:

1) Li et al. (2014), Chaetoglobosins from Chaetomium globosum, an endophytic fungus in Ginkgo biloba, and their phytotoxic and cytotoxic activities; J. Agric. Food Chem., 62 3734
2) Knudsen et al. (2014), Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton; Leukemia, 28 1289
3) Shinohara et al. (2000), Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B; J. Antibiot. (Tokyo), 53 262

CAS:
50335-03-0
Catalog Number:
10-3081
Activity:
Actin binding agent / Apoptosis inducer
Chemical Name:
(7S,13E, 16S, 17E, 19R, 21E)-6,7-Epoxy-19-hydroxy-10-(1H-indol-3-yl)-16,18-dimethyl-[13]cytochalasa- 13,17,21-triene-1,20,23-trione
Molecular Weight:
528.64
Molecular Formula:
C32H36N2O5
Solubility:
Soluble in DMSO (up to 5 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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