Chromomycin A3 | DNA Stain
CAS:
7059-24-7
Catalog Number:
10-2064
Activity:
DNA stain
Chemical Names:
Aburamycin B; CMA3; NSC-58514
Molecular Weight:
1183.25
Molecular Formula:
C57H82O26
Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 1 mg | $52.00 | ||
| 5 mg | $150.00 |
Chromomycin A3 (7059-24-7) is a DNA-binding agent specific for GC-rich sequences1 which may be used as a DNA stain2. Inhibits neuronal apoptosis induced by oxidative stress and DNA damage.3 Inhibits NFkB signaling.4 Used in a reliable method for evaluating sperm DNA integrity.5
References:
- Van Dyke et al. (1983), Chromomycin, Mithramycin and olivomycin binding sites on heterogeneous deoxyribonucleic acid. Footprinting with methidiumpropyl-EDTA)iron(II); Biochemistry, 22 2373
- Crissman and Tobey (1990), Specific staining of DNA with the fluorescent antibiotic, mithramycin, chromomycin, and olivomycin; Methods Cell Biol., 33 97
- Chatterjee et al. (2001), Sequence-selective DNA binding drugs mithramycin A and chromomycin A3 are potent inhibitors of neuronal apoptosis induced by oxidative stress and DNA damage in cortical neurons; Neurol., 49 345
- Miller et al. (2010), Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action; Pharmacol., 79 1272
- Dutta et al. (2020), Comparative analysis of tests used to assess sperm chromatin integrity and DNA fragmentation; Andrologia, 53 e13718
CAS:
7059-24-7
Catalog Number:
10-2064
Activity:
DNA stain
Chemical Names:
Aburamycin B; CMA3; NSC-58514
Molecular Weight:
1183.25
Molecular Formula:
C57H82O26
Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Chromomycin A3 (7059-24-7) is a DNA-binding agent specific for GC-rich sequences1 which may be used as a DNA stain2. Inhibits neuronal apoptosis induced by oxidative stress and DNA damage.3 Inhibits NFkB signaling.4 Used in a reliable method for evaluating sperm DNA integrity.5
References:
- Van Dyke et al. (1983), Chromomycin, Mithramycin and olivomycin binding sites on heterogeneous deoxyribonucleic acid. Footprinting with methidiumpropyl-EDTA)iron(II); Biochemistry, 22 2373
- Crissman and Tobey (1990), Specific staining of DNA with the fluorescent antibiotic, mithramycin, chromomycin, and olivomycin; Methods Cell Biol., 33 97
- Chatterjee et al. (2001), Sequence-selective DNA binding drugs mithramycin A and chromomycin A3 are potent inhibitors of neuronal apoptosis induced by oxidative stress and DNA damage in cortical neurons; Neurol., 49 345
- Miller et al. (2010), Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action; Pharmacol., 79 1272
- Dutta et al. (2020), Comparative analysis of tests used to assess sperm chromatin integrity and DNA fragmentation; Andrologia, 53 e13718
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