CIB-3b | Inhibitor of microRNA biogenesis
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $55.00 | ||
| 25 mg | $195.00 |
CIB-3b (124811-87-6) inhibits microRNA (miRNA) biogenesis via binding (KD = 10.42 nM) to transactivation response (TAR) RNA-binding protein 2 (TRBP), disrupting the TRBP-Dicer interaction, a critical element in pre-miRNA processing. It inhibited mi-R21 (EC50 = 1.38 µM) expression, a potent inducer of cellular EMT progression. CIB-3b inhibited hepatocarcinogenesis by blocking EMT in a mouse orthotopic transplantation model (SK-HEP-1 cells).
References/Citations:
- Peng, et al. (2022), Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis; J. Med. Chem., 65 11010
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
CIB-3b (124811-87-6) inhibits microRNA (miRNA) biogenesis via binding (KD = 10.42 nM) to transactivation response (TAR) RNA-binding protein 2 (TRBP), disrupting the TRBP-Dicer interaction, a critical element in pre-miRNA processing. It inhibited mi-R21 (EC50 = 1.38 µM) expression, a potent inducer of cellular EMT progression. CIB-3b inhibited hepatocarcinogenesis by blocking EMT in a mouse orthotopic transplantation model (SK-HEP-1 cells).
References/Citations:
- Peng, et al. (2022), Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis; J. Med. Chem., 65 11010
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