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Product Details

Cilastatin Na | Protease inhibitor

Cilastatin Na (81129-83-1) is a dehydropeptidase-1 inhibitor. Inhibits the proteolytic conversion of leukotriene D4 to E4.1  Inhibits the mammalian β-lactamase renal dipeptidase (dehydropeptidase-1, DPEP1) and thus is used as an antibacterial adjunct to extend the half-life of β-lactam antibiotics.2 Cilastatin also inhibits bacterial metallo-β-lactamase and thereby may block resistance to the carbapenem family of antibiotics in certain bacteria.3  Suppresses invasion and metastasis of DPEP1-expressing tumor cells.4  

 

References/Citations

1) White et al. (1999), A continuous fluorometric assay for Leukotriene D4 hydrolase; Anal. Biochem., 268 245
2) Graham et al. (1987), Inhibition of the mammalian beta-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-acylamino-3-substituted propenoic acids; J. Med. Chem., 30 1074
3) Keynan et al. (1995), The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA; Antimicreob. Agents Chemother., 39 1629
4) Park et al. (2016), Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer; Oncotarget, 7 9501

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Focus Biomolecules cell signaling reagent supplier, chemical structure Cilastatin Na | Protease inhibitor | CAS 81129-83-1

Catalog#  10-2233-0010

$60.00
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CAS:
81129-83-1
Catalog Number:
10-2233
Activity:
Protease inhibitor
Chemical Name:
(2Z)-7-[[(2R)-2-Amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]-carbonyl]amino]-2-heptenoic acid, sodium salt
Alternate Names:
MK 0791
Molecular Weight:
380.43
Molecular Formula:
C16H25N2O5S
Solubility:
Soluble in DMSO (up to 3 mg/ml) or in water (up to 35 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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