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Sinefungin | Methyltransferase inhibitor

Sinefungin (58944-73-3) is a nucleoside S-adenosyl-1-methionine analog. Potent, competitive methyltransferase (protein, DNA, and RNA methyltransferases) inhibitor.1,2 IC50 < 1.0 and 2.5 μM for PRMT1 and SET7/9, respectively.3 Sinefungin binds with greater affinity to the adenine-specific DNA methyltransferase M.TaqI than S-adenosyl-L-homocysteine.4 Inhibits biofilm formation by Streptococcus pneumoniae.5

References/Citations

1) Barbes et al. (1990), Effects of sinefungin and S-adenosylhomocysteine on DNA and protein methyltransferases from Streptomyces and other bacteria;  FEMS Microbiol. Lett., 57 239
2) Yebra et al. (1991), The effect of sinefungin and synthetic analogues on RNA and DNA methyltransferases from Streptomyces;  J. Antibiot. (Tokyo), 44 1141
3) Cheng et al. (2004), Small molecule regulators of protein arginine methyltransferases;  J. Biol. Chem., 279 23892
4) Schluckebier et al. (1997), Differential binding of S-andeosylmethionine S-adenosylhomocysteine and Sinefungin to adenine-specific DNA methyltransferase M. TaqI;  J. Mol. Biol., 265 56
5) Yadav et al. (2014), Sinefungin, a natural nucleoside analogue of S-adenosylmethionine, inhibits Streptococcus pneumonia biofilm growth;  Biomed. Res. Int., 2014 156987

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Focus Biomolecules cell signaling supplier, chemical structure of Sinefungin | Methyltransferase inhibitor | CAS 58944-73-3

Catalog#  10-2454

$60.00
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CAS:
58944-73-3
Catalog Number:
10-2454
Activity:
Methyltransferase inhibitor
Chemical Name:
5’-Deoxy-5’-(1,4-diamino-4-carboxybutyl)adenosine
Alternate Names:
A-9145; Adenosylornithine; Antibiotic 32232RP
Molecular Weight:
381.39
Molecular Formula:
C15H23N7O5
Solubility:
Soluble in Water (up to 20 mg/ml).
Physical Properties:
Tan solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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