Cinacalcet | Calcium sensing receptor (CaSR) agonist
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $50.00 | ||
| 50 mg | $100.00 |
Cinacalcet (364782-34-3) is a calcimimetic that allosterically activates the calcium-sensing receptor (CaSR; EC50 = 79.4 nM in HEK 293T cells expressing CaSR).1-3 It lowers plasma parathyroid hormone in hemodialysis patients with secondary hyperparathyroidism.4 Cinacalcet has been used to treat parathyroid carcinoma.5
References/Citations:
- Filapanti et al. (2013), Pharmacology of the calcium sensing receptor; Clin. Cases Miner. Bone Metab., 10 162
- Ma et al. (2011), Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor; J. Pharmacol. Exp. Ther., 337 275
- Nemeth (2004), Calcimimetic and calcilytic drugs: just for parathyroid cells?; Cell Calcium, 35 283
- Goodman et al. (2002), The Calcimimetic agent AMG 073 lowers plasma parathyroid hormone levels in hemodialysis patients with secondary hyperparathyroidism; J. Am. Soc. Nephrol., 13 1017
- Lumachi et al. (2006), Parathyroid cancer: etiology, clinical presentation and treatment; Anticancer Res., 26 4803
C22H22F3N
>98% by TLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Cinacalcet (364782-34-3) is a calcimimetic that allosterically activates the calcium-sensing receptor (CaSR; EC50 = 79.4 nM in HEK 293T cells expressing CaSR).1-3 It lowers plasma parathyroid hormone in hemodialysis patients with secondary hyperparathyroidism.4 Cinacalcet has been used to treat parathyroid carcinoma.5
References/Citations:
- Filapanti et al. (2013), Pharmacology of the calcium sensing receptor; Clin. Cases Miner. Bone Metab., 10 162
- Ma et al. (2011), Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor; J. Pharmacol. Exp. Ther., 337 275
- Nemeth (2004), Calcimimetic and calcilytic drugs: just for parathyroid cells?; Cell Calcium, 35 283
- Goodman et al. (2002), The Calcimimetic agent AMG 073 lowers plasma parathyroid hormone levels in hemodialysis patients with secondary hyperparathyroidism; J. Am. Soc. Nephrol., 13 1017
- Lumachi et al. (2006), Parathyroid cancer: etiology, clinical presentation and treatment; Anticancer Res., 26 4803
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