Cinnabarinic acid | Endogenous AhR ligand

CAS:
606-59-7
Catalog Number:
10-2883
Activity:
Endogenous AhR ligand
Chemical Name:
2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid
Alternate Names:
Cinnabaric acid
Molecular Weight:
300.22
Molecular Formula:
C14H8N2O6
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in DMF (up to 25 mg/ml).
Physical Properties:
Red solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$50.00
25 mg$198.00

Cinnabarinic acid (606-59-7) is a novel endogenous tryptophan metabolite which acts as an aryl hydrocarbon receptor (AHR) agonist.1 It drives IL-22 production by stimulating the differentiation of human and mouse T cells producing IL-22.1 Induces apoptosis in thymocytes.2 Activates type 4 metabotropic glutamate receptors.3 Cinnabarinic acid counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells. Displays neuroprotective activity.3

References/Citations:

1) Lowe et al. (2014), Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production;  PLoS One, 9(2) e87877
2) Hiramatsu et al. (2008), Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase;  J. Cell. Biochem., 103 42
3) Fazio et al. (2012), Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors;  Mol. Pharmacol., 81 643

CAS:
606-59-7
Catalog Number:
10-2883
Activity:
Endogenous AhR ligand
Chemical Name:
2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid
Alternate Names:
Cinnabaric acid
Molecular Weight:
300.22
Molecular Formula:
C14H8N2O6
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in DMF (up to 25 mg/ml).
Physical Properties:
Red solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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