Size: | Price | Quantity | |
---|---|---|---|
5 mg | $50.00 | ||
25 mg | $198.00 |
Cinnabarinic acid (606-59-7) is a novel endogenous tryptophan metabolite which acts as an aryl hydrocarbon receptor (AHR) agonist.1 It drives IL-22 production by stimulating the differentiation of human and mouse T cells producing IL-22.1 Induces apoptosis in thymocytes.2 Activates type 4 metabotropic glutamate receptors.3 Cinnabarinic acid counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells. Displays neuroprotective activity.3
References/Citations:
1) Lowe et al. (2014), Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production; PLoS One, 9(2) e87877
2) Hiramatsu et al. (2008), Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase; J. Cell. Biochem., 103 42
3) Fazio et al. (2012), Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors; Mol. Pharmacol., 81 643
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Cinnabarinic acid (606-59-7) is a novel endogenous tryptophan metabolite which acts as an aryl hydrocarbon receptor (AHR) agonist.1 It drives IL-22 production by stimulating the differentiation of human and mouse T cells producing IL-22.1 Induces apoptosis in thymocytes.2 Activates type 4 metabotropic glutamate receptors.3 Cinnabarinic acid counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells. Displays neuroprotective activity.3
References/Citations:
1) Lowe et al. (2014), Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production; PLoS One, 9(2) e87877
2) Hiramatsu et al. (2008), Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase; J. Cell. Biochem., 103 42
3) Fazio et al. (2012), Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors; Mol. Pharmacol., 81 643
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