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Product Details

Cisplatin | Anticancer agent

Induces intra- and interstrand DNA adducts which poison topoisomerase I.1 Synergizes with topoisomerase I inhibitors such as topotecan.1 Induces apoptosis by sequential activation of caspase-8, -3 and -6 in osteosarcoma cells.2 Inhibits expression of X-linked inhibitor of apoptosis protein (XIAP) in human LNCaP cells.3 Numerous mechanisms inhibit propagation of cisplatin-induced DNA damage to signal apoptosis resulting in resistance.4 Clinically useful anticancer agent.

References/Citations

1) Van Waardenburg et al. (2004), Platinated DNA adducts enhance poisoning of DNA topoisomerase I by camptothecin; J. Biol. Chem,, 279 54502
2) Siddik et al. (2003), Cisplatin: mode of cytotoxic action and molecular basis of resistance; Oncogene, 22 7265
3) Seki et al. (2000), Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma; Cancer Chemother. Pharmacol., 45 199
4) Nomura et al. (2004), Cisplatin inhibits the expression of X-linked inhibitor of apoptosis protein in human LNCaP cells; Urol. Oncol., 22 453
5) Raghavan et al. (2015), Dimethylsulfoxide inactivates the anticancer effect of cisplatin against myelogenous leukemia cell lines in in vitro assays.; Indian J. Phamracol., 47 322

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Catalog#  10-2204-0100

$50.00
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CAS:
15663-27-1
Catalog Number:
10-2204
Activity:
Anticancer agent
Chemical Name:
Cis-Diaminodichloroplatinum
Alternate Names:
CDDP; cis-Diamineplatinum(II) dichloride
Molecular Weight:
300.05
Molecular Formula:
Cl2H4N2Pt
Solubility:
Soluble in Water (up to 2.5 mg/ml with warming)
Physical Properties:
Yellow solid
Purity:
98% by HPLC
Elemental Analysis (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year as supplied. Solutions in distilled water are not stable and must be used within 1 working day. do not store solutions.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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