Clemastine fumarate | Histamine H1 receptor antagonist/Enhances Remyelination
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 20 mg | $35.00 | ||
| 100 mg | $80.00 |
Clemastine fumarate (14976-57-9) is a histamine H1 antagonist with anti-muscarinic effects at the M1 receptor. Enhances remyelination in a mouse model of demyelination.1 Displays protective role against neuroinflammation and demyelination via anti-inflammatory and anti-pyroptotic actions.2 Clemastine promoted oligodendrocyte differentiation in a rat model of spinal cord injury via muscarinic receptor mediated activation of ERK1/2 signaling.3
References/Citations:
- Li et al. (2015), Clemastine rescues behavioral changes and enhances remyelination in the cuprizone mouse model of demyelination; Neurosci. Bull. 31 617
- Motawi et al. (2023), Modulation of p38 MAPK and Nrf2/HO-1/NLRP3 inflammasome signaling and pyroptosis outline the anti-neuroinflammatory and remyelinating characters of Clemastine in EAE rat model; Biochem. Pharmacol. 209 115435
- Tong et al. (2022), Clemastine Promotes Differentiation of Oligodendrocyte Progenitor Cells Through the Activation of ERK1/2 via Muscarinic Receptors After Spinal Cord Injury; Front. Pharmacol. 13 914153
C21H26ClNO·C4H4O4
>98% by HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Clemastine fumarate (14976-57-9) is a histamine H1 antagonist with anti-muscarinic effects at the M1 receptor. Enhances remyelination in a mouse model of demyelination.1 Displays protective role against neuroinflammation and demyelination via anti-inflammatory and anti-pyroptotic actions.2 Clemastine promoted oligodendrocyte differentiation in a rat model of spinal cord injury via muscarinic receptor mediated activation of ERK1/2 signaling.3
References/Citations:
- Li et al. (2015), Clemastine rescues behavioral changes and enhances remyelination in the cuprizone mouse model of demyelination; Neurosci. Bull. 31 617
- Motawi et al. (2023), Modulation of p38 MAPK and Nrf2/HO-1/NLRP3 inflammasome signaling and pyroptosis outline the anti-neuroinflammatory and remyelinating characters of Clemastine in EAE rat model; Biochem. Pharmacol. 209 115435
- Tong et al. (2022), Clemastine Promotes Differentiation of Oligodendrocyte Progenitor Cells Through the Activation of ERK1/2 via Muscarinic Receptors After Spinal Cord Injury; Front. Pharmacol. 13 914153
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