Clodronate 2Na | Induces osteoclast apoptosis
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $30.00 | ||
| 50 mg | $70.00 |
Clodronate 2Na (88416-50-6) is a first generation non-nitrogenous bisphosphonate drug for the prevention and treatment of osteoporosis and skeletal fractures/hypercalcemia in patients with cancer. It strongly binds to hydroxyapatite and directly reduces osteoclast activity.1 Clodronate is metabolized in vitro to a cytotoxic ATP analog (AppCCl2p) which inhibits ADP/ATP translocase in the mitochondrial inner membrane leading to osteoclast apoptosis.2
References/Citations:
1) Plosker and Goa (1994), Clodronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease; Drugs 47 945
2) Lehenkari et al. (2002), Further Insight into Mechanism of Action of Clodronate: Inhibition of Mitochondrial ADP/ATP Translocase by a Nonhydrolyzable, Adenine-Containing Metabolite; Mol.Pharmacol. 61 1255
NMR (Conforms)
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Product Data Sheet:
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Clodronate 2Na (88416-50-6) is a first generation non-nitrogenous bisphosphonate drug for the prevention and treatment of osteoporosis and skeletal fractures/hypercalcemia in patients with cancer. It strongly binds to hydroxyapatite and directly reduces osteoclast activity.1 Clodronate is metabolized in vitro to a cytotoxic ATP analog (AppCCl2p) which inhibits ADP/ATP translocase in the mitochondrial inner membrane leading to osteoclast apoptosis.2
References/Citations:
1) Plosker and Goa (1994), Clodronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease; Drugs 47 945
2) Lehenkari et al. (2002), Further Insight into Mechanism of Action of Clodronate: Inhibition of Mitochondrial ADP/ATP Translocase by a Nonhydrolyzable, Adenine-Containing Metabolite; Mol.Pharmacol. 61 1255
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