Clozapine | Dopamine D2/D4 antagonist
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 100 mg | $50.00 | ||
| 500 mg | $170.00 |
Clozapine (5786-21-0) is a dopamine D4 and D2 receptor antagonist. High affinity for the cloned rat dopamine D4 receptor (Ki < 20 nM).1 Atypical neuroleptic agent.2 Antagonist at 5HT2A, 5HT2C, 5HT3, 5HT6 and 5HT7 receptors.3,4
References/Citations:
1) Seeman and Van Tol (1994), Dopamine receptor pharmacology; Trends Pharmacol. Sci., 15 264
2) Ellenbroek et al. (1991), The involvement of dopamine D1 and D2 receptors in the effects of the classical neuroleptic haloperidol and the atypical neuroleptic clozapine; Eur. J. Pharmacol., 196 103
3) Canton et al. (1990), Binding of the typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites; Eur. J. Pharmacol., 191 93
4) Kuoppamaki et al. (1993), Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists; Eur. J. Pharmacol., 245 179
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Clozapine (5786-21-0) is a dopamine D4 and D2 receptor antagonist. High affinity for the cloned rat dopamine D4 receptor (Ki < 20 nM).1 Atypical neuroleptic agent.2 Antagonist at 5HT2A, 5HT2C, 5HT3, 5HT6 and 5HT7 receptors.3,4
References/Citations:
1) Seeman and Van Tol (1994), Dopamine receptor pharmacology; Trends Pharmacol. Sci., 15 264
2) Ellenbroek et al. (1991), The involvement of dopamine D1 and D2 receptors in the effects of the classical neuroleptic haloperidol and the atypical neuroleptic clozapine; Eur. J. Pharmacol., 196 103
3) Canton et al. (1990), Binding of the typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites; Eur. J. Pharmacol., 191 93
4) Kuoppamaki et al. (1993), Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists; Eur. J. Pharmacol., 245 179
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