Concanamycin A | V-ATPase inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 20 µg | $60.00 | ||
| 100 µg | $120.00 |
Concanamycin A (80890-47-7) is a potent and specific inhibitor of the vacuolar (V-type) H+-ATPase which can induce apoptotic cell death in various cell lines.1,2 Inhibits cell surface expression of virus envelope glycoproteins.3 Dramatically increases the rate of extracellular vesicle release from a variety of cell types.4 Inhibits autophagy by blocking lysosomal acidification.5
References/Citations:
1) Nishihara et al. (1995), Specific inhibitors if vacuolar type H(+)-ATPases induce apoptotic cell death; Biochem. Biophys, Res. Commun., 212 255
2) Hong et al. (2006), Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells; J. Pharmacol. Exp. Ther., 319 672
3) Muroi et al. (1993), Folimycin (concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitis virus before arrival to the Golgi apparatus; Cell Struct. Function, 18 139
4) Cashikar and Hanson (1987), A cell-based assay for CD63-containing extracellular vesicles; PLoS One, 14 e0220007
5) Gradzka et al. (2018), Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes; Cell Death Dis., 9 529
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Concanamycin A (80890-47-7) is a potent and specific inhibitor of the vacuolar (V-type) H+-ATPase which can induce apoptotic cell death in various cell lines.1,2 Inhibits cell surface expression of virus envelope glycoproteins.3 Dramatically increases the rate of extracellular vesicle release from a variety of cell types.4 Inhibits autophagy by blocking lysosomal acidification.5
References/Citations:
1) Nishihara et al. (1995), Specific inhibitors if vacuolar type H(+)-ATPases induce apoptotic cell death; Biochem. Biophys, Res. Commun., 212 255
2) Hong et al. (2006), Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells; J. Pharmacol. Exp. Ther., 319 672
3) Muroi et al. (1993), Folimycin (concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitis virus before arrival to the Golgi apparatus; Cell Struct. Function, 18 139
4) Cashikar and Hanson (1987), A cell-based assay for CD63-containing extracellular vesicles; PLoS One, 14 e0220007
5) Gradzka et al. (2018), Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes; Cell Death Dis., 9 529
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