CPTH2 | HAT inhibitor

CAS:
357649-93-5
Catalog Number:
10-4528
Activity:
HAT inhibitor
Chemical Name:
Cyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl]hydrazone
Molecular Weight:
291.8
Molecular Formula:
C14H14ClN3S
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$69.00
25 mg$250.00

CPTH2 (357649-93-5) is a selective inhibitor of the histone acetyltransferase Gcn5P both in vitro and in vivo (IC50 = 0.8 mM). In vitro, the HAT inhibitory activity of CPTH2 was caused via bridge-interaction with histone H3. It’s in vivo activity may involve more histonic and/or non-histonic Gcn5p substrates.

References/Citations:

1) Chimenti et al. (2009), A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl]hydrazone); J. Med .Chem., 52 530

CAS:
357649-93-5
Catalog Number:
10-4528
Activity:
HAT inhibitor
Chemical Name:
Cyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl]hydrazone
Molecular Weight:
291.8
Molecular Formula:
C14H14ClN3S
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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