Crizotinib | c-MET and ALK inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $80.00 | ||
| 25 mg | $300.00 |
Crizotinib (877399-52-5) is a potent and selective inhibitor of c-MET and ALK, IC50‘s=8 and 20 nM respectively.1 Inhibition of cell proliferation was associated with G1-S phase cell cycle arrest and induction of apoptosis in ALK-positive ALCL cells (IC50=30 nM) but not in ALK-negative lymphoma cells.1 Exhibits cytoreductive antitumor efficacy via antiproliferative and antiangiogenic mechanisms.2 Clinically useful anticancer agent.3
References/Citations:
1) Christensen et al. (2007), Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma; Mol. Cancer Ther., 6 3314
2) Zou et al. (2007), An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms; Cancer Res., 67 4408
3) Bang et al. (2010), Clinical activity of the oral ALK inhibitor PF-02341066 in ALK-positive patients with non-small cell lung cancer (NSCLC); J. Clin. Oncol., 28 3
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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Crizotinib (877399-52-5) is a potent and selective inhibitor of c-MET and ALK, IC50‘s=8 and 20 nM respectively.1 Inhibition of cell proliferation was associated with G1-S phase cell cycle arrest and induction of apoptosis in ALK-positive ALCL cells (IC50=30 nM) but not in ALK-negative lymphoma cells.1 Exhibits cytoreductive antitumor efficacy via antiproliferative and antiangiogenic mechanisms.2 Clinically useful anticancer agent.3
References/Citations:
1) Christensen et al. (2007), Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma; Mol. Cancer Ther., 6 3314
2) Zou et al. (2007), An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms; Cancer Res., 67 4408
3) Bang et al. (2010), Clinical activity of the oral ALK inhibitor PF-02341066 in ALK-positive patients with non-small cell lung cancer (NSCLC); J. Clin. Oncol., 28 3
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