CT-2584 | Inhibitor of CTP: choline-phosphate cytidylyltransferase
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $125.00 | ||
| 25 mg | $475.00 |
CT-2584 (166981-13-1; free base) is a cytotoxic agent that alters phospholipid biosynthesis via inhibition of CTP:choline-phosphate cytidylyltransferase causing an increase in phosphatidylinositol with decreasing levels of phosphatidylcholine.1 The altered phospholipid metabolism caused by CT-2584 results in a loss of lamellar structure and membrane integrity (especially in mitochondria and endoplasmic reticulum). CT-2584 was active against a wide range of tumor cell lines including multi-drug resistant lines.2
References/Citations:
1) Finney et al. (2000), Pharmacological Inhibition of Phosphatidylcholine Biosynthesis is Associated with Induction of Phosphatidylinositol Accumulation and Cytolysis of Neoplastic Cell lines; Cancer Res., 60 5204
2) Cheeseman et al. (2000), Phase I and pharmacologic study of CT-2584 HMS, a modulator of phosphatidic acid, in adult patients with solid tumors; Br. J. Cancer, 83 1599
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
CT-2584 (166981-13-1; free base) is a cytotoxic agent that alters phospholipid biosynthesis via inhibition of CTP:choline-phosphate cytidylyltransferase causing an increase in phosphatidylinositol with decreasing levels of phosphatidylcholine.1 The altered phospholipid metabolism caused by CT-2584 results in a loss of lamellar structure and membrane integrity (especially in mitochondria and endoplasmic reticulum). CT-2584 was active against a wide range of tumor cell lines including multi-drug resistant lines.2
References/Citations:
1) Finney et al. (2000), Pharmacological Inhibition of Phosphatidylcholine Biosynthesis is Associated with Induction of Phosphatidylinositol Accumulation and Cytolysis of Neoplastic Cell lines; Cancer Res., 60 5204
2) Cheeseman et al. (2000), Phase I and pharmacologic study of CT-2584 HMS, a modulator of phosphatidic acid, in adult patients with solid tumors; Br. J. Cancer, 83 1599
Related products
-
CL-82198 | MMP-13 inhibitor
From $50.00CAS:307002-71-7Catalog Number:10-1028Activity:MMP-13 inhibitorChemical Name:N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamideMolecular Weight:302.37Molecular Formula:C17H22N2O3Solubility:Soluble in DMSO (up to 10 mg/ml).Physical Properties:Off-white solidPurity:>98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 6 months.Shipping Code:RT -
Imatinib mesylate | BCR-ABL inhibitor
From $30.00CAS:220127-57-1Catalog Number:10-1060Activity:BCR-ABL inhibitorAlternate Names:GleevecChemical Name:4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonateMolecular Weight:589.73Molecular Formula:C29H31N7O CH3SO3HSolubility:Soluble in DMSO (up to 50 mg/ml) or in Water (up to 50 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 3 months.Shipping Code:RT -
AG-1296 | PDGFR kinase inhibitor
From $60.00CAS:146535-11-7Catalog Number:10-1087Activity:PDGFR kinase inhibitorChemical Name:6,7-Dimethoxy-3-phenylquinoxalineMolecular Weight:266.3Molecular Formula:C16H14N2O2Solubility:Soluble in DMSO.Physical Properties:Yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
20% OFF
For Postdoc
Customers!
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.