Cycloastragenol | Telomerase activator/Senolytic agent
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 20 mg | $50.00 | ||
| 100 mg | $200.00 |
Cycloastragenol (84605-18-5) is a novel naturally occurring terpenoid found in Astragalus which was shown to be a telomerase activator. In CD8+ T lymphocytes from HIV-infected donors it retarded telomere shortening, increased proliferative potential and enhanced cytokine/chemokine production and antiviral activity.1 It suppressed lung damage in a idiopathic pulmonary fibrosis mouse model.2 It has also been shown to be a novel senolytic agent, inducing senescent cell apoptosis and restoring physical function in mice with irradiation-induced aging.3
References/Citations:
- Fauce et al. (2008), Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8+ T Lymphocytes; J. Immunol. 181 7400
- Le Saux et al. (2013), A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis; PLoS One 8 e58423
- Zhang et al. (2023), Cycloastragenol: A Novel Senolytic Agent That Induces Senescent Cell Apoptosis and Restores Physical Function in TBI-Aged Mice; Int. J. Mol. Sci. 24 6554
C30H50O5
>98% by HPLC
NMR: Conforms
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Cycloastragenol (84605-18-5) is a novel naturally occurring terpenoid found in Astragalus which was shown to be a telomerase activator. In CD8+ T lymphocytes from HIV-infected donors it retarded telomere shortening, increased proliferative potential and enhanced cytokine/chemokine production and antiviral activity.1 It suppressed lung damage in a idiopathic pulmonary fibrosis mouse model.2 It has also been shown to be a novel senolytic agent, inducing senescent cell apoptosis and restoring physical function in mice with irradiation-induced aging.3
References/Citations:
- Fauce et al. (2008), Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8+ T Lymphocytes; J. Immunol. 181 7400
- Le Saux et al. (2013), A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis; PLoS One 8 e58423
- Zhang et al. (2023), Cycloastragenol: A Novel Senolytic Agent That Induces Senescent Cell Apoptosis and Restores Physical Function in TBI-Aged Mice; Int. J. Mol. Sci. 24 6554
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