D(+)-Cycloserine | NMDA, glycine site partial agonist
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 1 gram | $60.00 | ||
| 5 gram | $240.00 |
D-Cycloserine (68-41-7) is a partial agonist at the glycine modulatory site of NMDA glutamatergic receptors.1 Blocks kainate-induced seizures2 and displays anticonvulsant effects3 in rat models. D-Cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices.4 Second-line drug for the treatment of tuberculosis. Enhances activity-dependent plasticity in human adults.5
References/Citations:
1) Watson et al. (1990), D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes; Brain Res., 510 158
2) Baran et al. (1994), The glycine/NMDA receptor partial agonist D-cycloserine blocks kainite-induced seizures in rats. Comparison with MK-801 and diazepam; Brain Res., 652 195
3) Löscher et al. (1994), Anticonvulsant effects of the glycine/NMDA receptor ligands D-cycloserine and D-serine but not R(+)-HA-966 in amygdala-kindled rats; Br. J. Pharmacol., 112 97
4) Rouaud and Billard (2003), D-cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices; Br. J. Pharmacol., 140 1051
5) Forsyth et al. (2015), Augmenting NMDA receptor signaling boosts experience-dependent neuroplasticity in the adult human brain; Proc. Natl. Acad. Sci. USA, 112 15331
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
D-Cycloserine (68-41-7) is a partial agonist at the glycine modulatory site of NMDA glutamatergic receptors.1 Blocks kainate-induced seizures2 and displays anticonvulsant effects3 in rat models. D-Cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices.4 Second-line drug for the treatment of tuberculosis. Enhances activity-dependent plasticity in human adults.5
References/Citations:
1) Watson et al. (1990), D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes; Brain Res., 510 158
2) Baran et al. (1994), The glycine/NMDA receptor partial agonist D-cycloserine blocks kainite-induced seizures in rats. Comparison with MK-801 and diazepam; Brain Res., 652 195
3) Löscher et al. (1994), Anticonvulsant effects of the glycine/NMDA receptor ligands D-cycloserine and D-serine but not R(+)-HA-966 in amygdala-kindled rats; Br. J. Pharmacol., 112 97
4) Rouaud and Billard (2003), D-cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices; Br. J. Pharmacol., 140 1051
5) Forsyth et al. (2015), Augmenting NMDA receptor signaling boosts experience-dependent neuroplasticity in the adult human brain; Proc. Natl. Acad. Sci. USA, 112 15331
Related products
-
MAC-545496 | GraR inhibitor
From $60.00CAS:838810-96-1Catalog Number:10-3951Activity:GraR inhibitorChemical Names:N-[(5-Chloropyridin-2-yl)carbamothioyl]-3-nitro-4-piperidin-1-ylbenzamideMolecular Weight:419.88Molecular Formula:C18H18ClN5O3SSolubility:Soluble in DMSO (25 mg/ml)Physical Properties:Yellow/orange solidPurity:98% TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 monthShipping Code:RT -
Celastrol | Proteasome inhibitor
From $50.00CAS:34157-83-0Catalog Number:10-2187Activity:Proteasome inhibitorChemical Name:(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acidMolecular Weight:450.62Molecular Formula:C29H38O4Solubility:Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 30 mg/ml).Physical Properties:Red SolidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.Shipping Code:RT -
Sulfasalazine | Anti-inflammatory / antibiotic
From $20.00CAS:599-79-1Catalog Number:10-4566Activity:Anti-inflammatory / antibioticChemical Name:2-Hydroxy-5-{{4-[(2-pyridinylamino)sulfonyl]phenyl}azo}benzoic acidMolecular Weight:398.39Molecular Formula:C18H14N4O5SSolubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:Orange solidPurity:98%
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
