Cytosporone B | Nur77 agonist

Cytosporone B chemical structure

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Cytosporone B (321661-62-5) is a naturally occurring agonist (EC50 = 0.28 nM) of nuclear receptor Nur77.1 It elevated blood glucose levels in fasting mice and induced apoptosis in mouse tumor xenografts. Cytosporone B reduced proinflammatory mediators in various models.2-5 It  inhibited esophageal squamous cell carcinoma growth and enhanced anti-PD-1 therapy efficacy.6 Cytosporone B enhanced the anti-tumor activity of natural killer cells against hepatocellular carcinoma.7

References/Citations:

  1. Zhan et al. (2008), Cytosprone B is an agonist for nuclear orphan receptor Nur77; Nat. Chem. Biol. 4 548
  2. Wu et al. (2016), NUR77 exerts a protective effect against inflammatory disease by negatively regulating the TRAF6/TLR-IL-1R axis; J. Pathol. 238 457
  3. Liu et al. (2017), Activation of Nur77 in microglia attenuates proinflammatory mediator production and protects dopaminergic neurons from inflammation-induced cell death; J. Neurochem. 140 589
  4. Ismaiel et al. (2021), The NR4A agonist, Cytosporone B, attenuates pro-inflammatory mediators in human colorectal cancer tissue ex vivo.; Biochem. Biophys. Res. Commun. 554 179
  5. Patino-Martinez et al. (2022), The Nur77 agonist Cytosporone B differentially regulates inflammatory responses in human polarized macrophages; Immunobiology 227 152299
  6. Shi et al. (2024), Nur77-IRF1 axis inhibits esophageal squamous cell carcinoma growth and improves anti-PD-1 treatment efficacy.; Cell Death Discov. 10 254
  7. Neo et al. (2026), Nur77 agonism invigorates Natural Killer cell immunity against hepatocellular carcinoma.; Nat. Commun. 10 Online ahead of publication
321661-62-5, Cytosporone B, Cytosporone B supplier, Nur77 agonist

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Cytosporone B (321661-62-5) is a naturally occurring agonist (EC50 = 0.28 nM) of nuclear receptor Nur77.1 It elevated blood glucose levels in fasting mice and induced apoptosis in mouse tumor xenografts. Cytosporone B reduced proinflammatory mediators in various models.2-5 It  inhibited esophageal squamous cell carcinoma growth and enhanced anti-PD-1 therapy efficacy.6 Cytosporone B enhanced the anti-tumor activity of natural killer cells against hepatocellular carcinoma.7

References/Citations:

  1. Zhan et al. (2008), Cytosprone B is an agonist for nuclear orphan receptor Nur77; Nat. Chem. Biol. 4 548
  2. Wu et al. (2016), NUR77 exerts a protective effect against inflammatory disease by negatively regulating the TRAF6/TLR-IL-1R axis; J. Pathol. 238 457
  3. Liu et al. (2017), Activation of Nur77 in microglia attenuates proinflammatory mediator production and protects dopaminergic neurons from inflammation-induced cell death; J. Neurochem. 140 589
  4. Ismaiel et al. (2021), The NR4A agonist, Cytosporone B, attenuates pro-inflammatory mediators in human colorectal cancer tissue ex vivo.; Biochem. Biophys. Res. Commun. 554 179
  5. Patino-Martinez et al. (2022), The Nur77 agonist Cytosporone B differentially regulates inflammatory responses in human polarized macrophages; Immunobiology 227 152299
  6. Shi et al. (2024), Nur77-IRF1 axis inhibits esophageal squamous cell carcinoma growth and improves anti-PD-1 treatment efficacy.; Cell Death Discov. 10 254
  7. Neo et al. (2026), Nur77 agonism invigorates Natural Killer cell immunity against hepatocellular carcinoma.; Nat. Commun. 10 Online ahead of publication