Cytosporone B | Nur77 agonist
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $195.00 |
Cytosporone B (321661-62-5) is a naturally occurring agonist (EC50 = 0.28 nM) of nuclear receptor Nur77.1 It elevated blood glucose levels in fasting mice and induced apoptosis in mouse tumor xenografts. Cytosporone B reduced proinflammatory mediators in various models.2-5 It inhibited esophageal squamous cell carcinoma growth and enhanced anti-PD-1 therapy efficacy.6 Cytosporone B enhanced the anti-tumor activity of natural killer cells against hepatocellular carcinoma.7
References/Citations:
- Zhan et al. (2008), Cytosprone B is an agonist for nuclear orphan receptor Nur77; Nat. Chem. Biol. 4 548
- Wu et al. (2016), NUR77 exerts a protective effect against inflammatory disease by negatively regulating the TRAF6/TLR-IL-1R axis; J. Pathol. 238 457
- Liu et al. (2017), Activation of Nur77 in microglia attenuates proinflammatory mediator production and protects dopaminergic neurons from inflammation-induced cell death; J. Neurochem. 140 589
- Ismaiel et al. (2021), The NR4A agonist, Cytosporone B, attenuates pro-inflammatory mediators in human colorectal cancer tissue ex vivo.; Biochem. Biophys. Res. Commun. 554 179
- Patino-Martinez et al. (2022), The Nur77 agonist Cytosporone B differentially regulates inflammatory responses in human polarized macrophages; Immunobiology 227 152299
- Shi et al. (2024), Nur77-IRF1 axis inhibits esophageal squamous cell carcinoma growth and improves anti-PD-1 treatment efficacy.; Cell Death Discov. 10 254
- Neo et al. (2026), Nur77 agonism invigorates Natural Killer cell immunity against hepatocellular carcinoma.; Nat. Commun. 10 Online ahead of publication
C18H26O5
>98% TLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Cytosporone B (321661-62-5) is a naturally occurring agonist (EC50 = 0.28 nM) of nuclear receptor Nur77.1 It elevated blood glucose levels in fasting mice and induced apoptosis in mouse tumor xenografts. Cytosporone B reduced proinflammatory mediators in various models.2-5 It inhibited esophageal squamous cell carcinoma growth and enhanced anti-PD-1 therapy efficacy.6 Cytosporone B enhanced the anti-tumor activity of natural killer cells against hepatocellular carcinoma.7
References/Citations:
- Zhan et al. (2008), Cytosprone B is an agonist for nuclear orphan receptor Nur77; Nat. Chem. Biol. 4 548
- Wu et al. (2016), NUR77 exerts a protective effect against inflammatory disease by negatively regulating the TRAF6/TLR-IL-1R axis; J. Pathol. 238 457
- Liu et al. (2017), Activation of Nur77 in microglia attenuates proinflammatory mediator production and protects dopaminergic neurons from inflammation-induced cell death; J. Neurochem. 140 589
- Ismaiel et al. (2021), The NR4A agonist, Cytosporone B, attenuates pro-inflammatory mediators in human colorectal cancer tissue ex vivo.; Biochem. Biophys. Res. Commun. 554 179
- Patino-Martinez et al. (2022), The Nur77 agonist Cytosporone B differentially regulates inflammatory responses in human polarized macrophages; Immunobiology 227 152299
- Shi et al. (2024), Nur77-IRF1 axis inhibits esophageal squamous cell carcinoma growth and improves anti-PD-1 treatment efficacy.; Cell Death Discov. 10 254
- Neo et al. (2026), Nur77 agonism invigorates Natural Killer cell immunity against hepatocellular carcinoma.; Nat. Commun. 10 Online ahead of publication
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