Daminozide | KDM2/7 demethylase inhibitor
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 50 mg | $40.00 | ||
| 250 mg | $90.00 |
Daminozide (1596-84-5) is a selective inhibitor of the KDM2/7 JmjC subfamily of histone demethylases. IC50=1.5, 0.55 and 2.1 μM for KDM2A, PHF8 and KDM7A respectively. Highly selective over other subfamily members (KDM3, KDM4, KDM5 and KDM6) as well as other 2-oxoglutarate oxygenases (FIH, PHD2 and BBOX1), IC50 > 100 μM.1 Decreases tumorsphere formation in human breast cancer cells and acts synergistically with cisplatin in cell killing.2
References/Citations:
1) Rose et al. (2012), Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone methylases; J. Med. Chem., 55 6639
2) Chen et al. (2016), Lysine demethylase 2A promotes stemness and angiogenesis of breast cancer by upregulating Jagged1; Oncotarget, 7 27689
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Daminozide (1596-84-5) is a selective inhibitor of the KDM2/7 JmjC subfamily of histone demethylases. IC50=1.5, 0.55 and 2.1 μM for KDM2A, PHF8 and KDM7A respectively. Highly selective over other subfamily members (KDM3, KDM4, KDM5 and KDM6) as well as other 2-oxoglutarate oxygenases (FIH, PHD2 and BBOX1), IC50 > 100 μM.1 Decreases tumorsphere formation in human breast cancer cells and acts synergistically with cisplatin in cell killing.2
References/Citations:
1) Rose et al. (2012), Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone methylases; J. Med. Chem., 55 6639
2) Chen et al. (2016), Lysine demethylase 2A promotes stemness and angiogenesis of breast cancer by upregulating Jagged1; Oncotarget, 7 27689
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