Damnacanthal | p56 Lck inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 1 mg | $130.00 | ||
| 5 mg | $520.00 |
Damnacanthal (477-84-9) is a potent inhibitor of p56lck tyrosine kinase activity (IC50 = 17 nM for inhibition of autophosphorylation). Displays 7- to 20-fold selectivity over p59fyn and p60src tyrosine kinases and > 40-fold to 100-fold selectivity over other kinases.1 Mobilizes intracellular Ca2+ in dermal fibroblasts.2 Inhibits LIM-kinase, impairing cell migration and invasion.3 A potent inhibitor of angiogenesis.4 Inhibits mast cell activation.5
References/Citations:
1) Faltynek et al. (1995), Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity; Biochemistry, 34 12404
2) Aoki et al. (2000), Mechanism of damnacanthal-induced ;Ca(2+)](i) elevation in human dermal fibroblasts; Eur. J. Pharmacol., 387 119
3) Ohashi et al. (2014), Damnacanthal, an effective inhibitor of LIM-kinase, inhibits cell migration and invasion; Mol. Biol. Cell, 25 828
4) Garcia-Vilas et al. (2017), The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects; Cancer Letters, 385 1
5) Garcia-Vilas et al. (2015), Damnacanthal inhibits IgE receptor-mediated activation of mast cells; Mol. Immunol., 65 86
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Damnacanthal (477-84-9) is a potent inhibitor of p56lck tyrosine kinase activity (IC50 = 17 nM for inhibition of autophosphorylation). Displays 7- to 20-fold selectivity over p59fyn and p60src tyrosine kinases and > 40-fold to 100-fold selectivity over other kinases.1 Mobilizes intracellular Ca2+ in dermal fibroblasts.2 Inhibits LIM-kinase, impairing cell migration and invasion.3 A potent inhibitor of angiogenesis.4 Inhibits mast cell activation.5
References/Citations:
1) Faltynek et al. (1995), Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity; Biochemistry, 34 12404
2) Aoki et al. (2000), Mechanism of damnacanthal-induced ;Ca(2+)](i) elevation in human dermal fibroblasts; Eur. J. Pharmacol., 387 119
3) Ohashi et al. (2014), Damnacanthal, an effective inhibitor of LIM-kinase, inhibits cell migration and invasion; Mol. Biol. Cell, 25 828
4) Garcia-Vilas et al. (2017), The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects; Cancer Letters, 385 1
5) Garcia-Vilas et al. (2015), Damnacanthal inhibits IgE receptor-mediated activation of mast cells; Mol. Immunol., 65 86
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