Dantrolene Na | SR calcium release inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 100 mg | $50.00 | ||
| 250 mg | $90.00 |
Dantrolene Na (14663-23-1) inhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor channels with selectivity for RYR1 and RYR3 over RYR2.1 Protects against quisqualate and NMDA-induced cytotoxicity in cultured cerebral cortical neurons.2 Displays neuroprotective effects.3 Prevents cell death in neural progenitor cells derived from Wolfram syndrome iPS cells.4
References/Citations:
1) Zhao et al. (2001), Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity; J. Biol. Chem., 276 13810
2) Frandsen and Schousboe (1992), Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate and kainite in cultured cerebral cortical neurons; Proc. Natl. Acad. Sci. USA, 89 2590
3) Muehlschlegel and Sims (2009), Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit; Neuro. Crit. Care, 10 103
4) Lu et al. (2014), A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome; Proc. Natl. Acad. Sci. USA, 111 E5292
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Dantrolene Na (14663-23-1) inhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor channels with selectivity for RYR1 and RYR3 over RYR2.1 Protects against quisqualate and NMDA-induced cytotoxicity in cultured cerebral cortical neurons.2 Displays neuroprotective effects.3 Prevents cell death in neural progenitor cells derived from Wolfram syndrome iPS cells.4
References/Citations:
1) Zhao et al. (2001), Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity; J. Biol. Chem., 276 13810
2) Frandsen and Schousboe (1992), Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate and kainite in cultured cerebral cortical neurons; Proc. Natl. Acad. Sci. USA, 89 2590
3) Muehlschlegel and Sims (2009), Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit; Neuro. Crit. Care, 10 103
4) Lu et al. (2014), A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome; Proc. Natl. Acad. Sci. USA, 111 E5292
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