DBeQ | p97 inhibitor

CAS:
177355-84-9
Catalog Number:
10-1196
Activity:
p97 inhibitor
Chemical Name:
N,N’-Dibenzylquinazoline-2,4-diamine
Molecular Weight:
340.43
Molecular Formula:
C22H20N4
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Available Options

size :PriceQuantity 
5 mg$65.00
25 mg$224.00

DBeQ (177355-84-9) is a potent, selective and reversible inhibitor of the AAA-ATPase p97 (ATPase associated with diverse cellular activities). Ki=3.2 μM. DBeQ blocks ubiquitin-dependent protein clearance pathways. Cell permeable.

References/Citations:

1) Chou et al. (2011), Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways; Proc. Natl. Acad. Sci. USA, 108 4834

CAS:
177355-84-9
Catalog Number:
10-1196
Activity:
p97 inhibitor
Chemical Name:
N,N’-Dibenzylquinazoline-2,4-diamine
Molecular Weight:
340.43
Molecular Formula:
C22H20N4
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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