DC260126 | GPR40 antagonist
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $48.00 | ||
| 25 mg | $155.00 |
DC260126 (346692-04-4) is a GPR40 receptor antagonist.1 Suppresses fatty acid-induced elevation of intracellular Ca++. Inhibits palmitic acid potentiated glucose-stimulated insulin secretion in Min6 pancreatic β cells in vitro. DC260126 lowers serum insulin levels, increases insulin sensitivity in obese Zucker rats (6 mg/kg).2 Reduces pancreatic β cell apoptosis in obese diabetic (db/db) rats.3 Protects Min6 β cells from palmitic acid-induced ER stress and apoptosis.4
References/Citations:
1) Hu et al. (2009), A novel class of antagonist for the FFAs receptor GPR40; Biochem. Biophys. Res. Commun., 390 557
2) Zhang et al. (2010), DC260126, a small molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats; Biomed. Pharmacother., 64 647
3) Sun et al. (2013), DC260126: a small molecule antagonist of GPR40 that protects against pancreatic β-cells dysfunction in db/db mice; PLoS One., 8(6) e66744
4) Wu et al. (2012), Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis; J. Biochem, 113 1152
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
DC260126 (346692-04-4) is a GPR40 receptor antagonist.1 Suppresses fatty acid-induced elevation of intracellular Ca++. Inhibits palmitic acid potentiated glucose-stimulated insulin secretion in Min6 pancreatic β cells in vitro. DC260126 lowers serum insulin levels, increases insulin sensitivity in obese Zucker rats (6 mg/kg).2 Reduces pancreatic β cell apoptosis in obese diabetic (db/db) rats.3 Protects Min6 β cells from palmitic acid-induced ER stress and apoptosis.4
References/Citations:
1) Hu et al. (2009), A novel class of antagonist for the FFAs receptor GPR40; Biochem. Biophys. Res. Commun., 390 557
2) Zhang et al. (2010), DC260126, a small molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats; Biomed. Pharmacother., 64 647
3) Sun et al. (2013), DC260126: a small molecule antagonist of GPR40 that protects against pancreatic β-cells dysfunction in db/db mice; PLoS One., 8(6) e66744
4) Wu et al. (2012), Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis; J. Biochem, 113 1152
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