Decoyinine | Inhibitor of GMP synthase

Decoyinine (2004-04-8) is a non-competitive and reversible inhibitor of GMP synthase (GMPS, IC₅₀=17.3 µM).¹  GMPS was shown to be a positive regulator of invasiveness in melanoma cells and decoyinine reduced invasion of melanoma cells by 30%.² Decoyinine reduces intracellular levels of GMP, GDP and GTP. Numerous studies of decoyinine in bacteria have been performed showing that guanylates play key roles in bacterial growth, cell wall biosynthesis, sporulation, and pathogenicity.^3-5

References/Citations:

1. Sundaram et al. (1984), Biochemical characterization of human GMP synthetase; J. Neurochem. 42 577
2. Ribbens et al. (2014); Pharmacological targeting of guanosine monophosphate synthase suppresses melanoma cell invasion and tumorigenicity, Mol. Genet. Metab., 111 172
3. Lewandowski et al. (2022), Expression of kinA and kinB of Bacillus subtilis, necessary for sporulation initiation, is under positive stringent transcription control; JCI Insight 7 e156301
4. Granzotto et al. (2019), Effect of decoyinine on the regulation of alpha-amylase synthesis in Bacillus subtilis; Aging (Albany NY) 11 6336
5. Granzotto et al. (2019), Effect of decoyinine on peptidoglycan synthesis and turnover in Bacillus subtilis; Aging (Albany NY) 11 6336