Size : | Price | Quantity | |
---|---|---|---|
5 mg | $50.00 | ||
25 mg | $120.00 |
Deltamethrin (52918-63-5) is reported to be an inhibitor of calcineurin (PP2B), IC50~100 pM1 but this activity has been disputed2. Markedly enhances the expression of BDNF in cultured rat cortical neurons and displays neurotrophic effects.3 Produces antidepressant-like effects in mice.4 Blocks the spontaneous down-regulation of Nav1.8 sodium channels expressed in Xenopus oocytes.5
References/Citations
1) Enan et al. (1992), Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides; Biochem. Pharmacol., 43 1777
2) Swingle et al. (2007), Small-molecules inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse; Methods Mol. Biol., 365 23
3) Ihara et al. (2012), Deltamethrin, a type II pyrethroid insecticide, has neurotrophic effects on neurons with continuous activation of the Bdnf promoter; Neuropharmacology, 62 1091
4) Takasaki et al. (2013), Type II pyrethroid deltamethrin produces antidepressant-like effects in mice; Behav. Brain Res., 257 182
5) Choi & Soderlund (2004), Cyclosporin A and deltamethrin block the downregulation of Nav1.8 sodium channels expressed in Xenopus oocytes; Neurosci. Lett., 367 389
.
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Deltamethrin (52918-63-5) is reported to be an inhibitor of calcineurin (PP2B), IC50~100 pM1 but this activity has been disputed2. Markedly enhances the expression of BDNF in cultured rat cortical neurons and displays neurotrophic effects.3 Produces antidepressant-like effects in mice.4 Blocks the spontaneous down-regulation of Nav1.8 sodium channels expressed in Xenopus oocytes.5
References/Citations
1) Enan et al. (1992), Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides; Biochem. Pharmacol., 43 1777
2) Swingle et al. (2007), Small-molecules inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse; Methods Mol. Biol., 365 23
3) Ihara et al. (2012), Deltamethrin, a type II pyrethroid insecticide, has neurotrophic effects on neurons with continuous activation of the Bdnf promoter; Neuropharmacology, 62 1091
4) Takasaki et al. (2013), Type II pyrethroid deltamethrin produces antidepressant-like effects in mice; Behav. Brain Res., 257 182
5) Choi & Soderlund (2004), Cyclosporin A and deltamethrin block the downregulation of Nav1.8 sodium channels expressed in Xenopus oocytes; Neurosci. Lett., 367 389
.
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