Deltamethrin | Calcineurin inhibitor/displays neurotrophic activity
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $120.00 |
Deltamethrin (52918-63-5) is reported to be an inhibitor of calcineurin (PP2B), IC50~100 pM1 but this activity has been disputed2. Markedly enhances the expression of BDNF in cultured rat cortical neurons and displays neurotrophic effects.3 Produces antidepressant-like effects in mice.4 Blocks the spontaneous down-regulation of Nav1.8 sodium channels expressed in Xenopus oocytes.5
References/Citations
1) Enan et al. (1992), Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides; Biochem. Pharmacol., 43 1777
2) Swingle et al. (2007), Small-molecules inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse; Methods Mol. Biol., 365 23
3) Ihara et al. (2012), Deltamethrin, a type II pyrethroid insecticide, has neurotrophic effects on neurons with continuous activation of the Bdnf promoter; Neuropharmacology, 62 1091
4) Takasaki et al. (2013), Type II pyrethroid deltamethrin produces antidepressant-like effects in mice; Behav. Brain Res., 257 182
5) Choi & Soderlund (2004), Cyclosporin A and deltamethrin block the downregulation of Nav1.8 sodium channels expressed in Xenopus oocytes; Neurosci. Lett., 367 389
.
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Deltamethrin (52918-63-5) is reported to be an inhibitor of calcineurin (PP2B), IC50~100 pM1 but this activity has been disputed2. Markedly enhances the expression of BDNF in cultured rat cortical neurons and displays neurotrophic effects.3 Produces antidepressant-like effects in mice.4 Blocks the spontaneous down-regulation of Nav1.8 sodium channels expressed in Xenopus oocytes.5
References/Citations
1) Enan et al. (1992), Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides; Biochem. Pharmacol., 43 1777
2) Swingle et al. (2007), Small-molecules inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse; Methods Mol. Biol., 365 23
3) Ihara et al. (2012), Deltamethrin, a type II pyrethroid insecticide, has neurotrophic effects on neurons with continuous activation of the Bdnf promoter; Neuropharmacology, 62 1091
4) Takasaki et al. (2013), Type II pyrethroid deltamethrin produces antidepressant-like effects in mice; Behav. Brain Res., 257 182
5) Choi & Soderlund (2004), Cyclosporin A and deltamethrin block the downregulation of Nav1.8 sodium channels expressed in Xenopus oocytes; Neurosci. Lett., 367 389
.
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