Deoxymannojirimycin HCl | Mannosidase inhibitor

CAS:
73465-43-7
Catalog Number:
10-2798
Activity:
Mannosidase inhibitor
Chemical Name:
2R-(Hydroxymethyl)-3R,4R,5R-piperidinetriol hydrochloride
Alternate Names:
1,5-Dideoxy-1,5-imino-D-mannitol hydrochloride
Molecular Weight:
199.63
Molecular Formula:
C6H13NO4 • HCl
Solubility:
Soluble in Water (up to 5 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
1 mg$40.00
5 mg$124.00

Deoxymannojirimycin HCl (CAS 73465-43-7) is a potent and selective inhibitor of α-mannosidase I.1,2 Inhibits the conversion of high mannose to complex oligosaccharides.3 Attenuates tunicamycin-, thapsigargin- and Aβ1-42-induced ER stress dependent neuronal cell death and protects primary cultured mouse cortical neurons from Aβ1-42 toxicity.4 Increases titers (4 fold) in the production of lentivirus vectors with enhanced efficiency in targeting dendritic cells.5,6

References/Citations:

1) Bischoff et al. (1986), The use of 1-deoxymannojirimycin to evaluated the role of various alpha-mannosidases in oligosaccharide processing in intact cells; J. Biol. Chem., 261 4766
2) Bischoff et al. (1984), The effect of 1-deoxymannojirimycin on rat liver alpha mannosidases.; Biochem. Biophys. Res. Commun., 125 324
3) Fuhrmann et al. (1984), Novel mannosidase inhibitor blocking conversation of high mannose to complex oligosaccharides; Nature, 307 755
4) Miyake and Nagai (2009), Inhibition of alpha-mannosidase attenuates endoplasmic reticulum stress-induced neuronal cell death; Neurotoxicology, 30 144
5) Tai et al. (2011), Production of lentiviral vectors with enhanced efficiency to target dendritic cells by attenuating mannosidase activity of mammalian  cells; J. Biol. Eng.,1
6) Lee et al. (2012), Construction of stable producer cells to make high-titer lentiviral vectors for dendritic cell-based vaccination; Biotechnol. Bioeng., 109 1551

CAS:
73465-43-7
Catalog Number:
10-2798
Activity:
Mannosidase inhibitor
Chemical Name:
2R-(Hydroxymethyl)-3R,4R,5R-piperidinetriol hydrochloride
Alternate Names:
1,5-Dideoxy-1,5-imino-D-mannitol hydrochloride
Molecular Weight:
199.63
Molecular Formula:
C6H13NO4 • HCl
Solubility:
Soluble in Water (up to 5 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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