Deoxymannojirimycin HCl | Mannosidase inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 1 mg | $40.00 | ||
| 5 mg | $124.00 |
Deoxymannojirimycin HCl (CAS 73465-43-7) is a potent and selective inhibitor of α-mannosidase I.1,2 Inhibits the conversion of high mannose to complex oligosaccharides.3 Attenuates tunicamycin-, thapsigargin- and Aβ1-42-induced ER stress dependent neuronal cell death and protects primary cultured mouse cortical neurons from Aβ1-42 toxicity.4 Increases titers (4 fold) in the production of lentivirus vectors with enhanced efficiency in targeting dendritic cells.5,6
References/Citations:
1) Bischoff et al. (1986), The use of 1-deoxymannojirimycin to evaluated the role of various alpha-mannosidases in oligosaccharide processing in intact cells; J. Biol. Chem., 261 4766
2) Bischoff et al. (1984), The effect of 1-deoxymannojirimycin on rat liver alpha mannosidases.; Biochem. Biophys. Res. Commun., 125 324
3) Fuhrmann et al. (1984), Novel mannosidase inhibitor blocking conversation of high mannose to complex oligosaccharides; Nature, 307 755
4) Miyake and Nagai (2009), Inhibition of alpha-mannosidase attenuates endoplasmic reticulum stress-induced neuronal cell death; Neurotoxicology, 30 144
5) Tai et al. (2011), Production of lentiviral vectors with enhanced efficiency to target dendritic cells by attenuating mannosidase activity of mammalian cells; J. Biol. Eng., 5 1
6) Lee et al. (2012), Construction of stable producer cells to make high-titer lentiviral vectors for dendritic cell-based vaccination; Biotechnol. Bioeng., 109 1551
NMR (Conforms)
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Product Data Sheet:
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Deoxymannojirimycin HCl (CAS 73465-43-7) is a potent and selective inhibitor of α-mannosidase I.1,2 Inhibits the conversion of high mannose to complex oligosaccharides.3 Attenuates tunicamycin-, thapsigargin- and Aβ1-42-induced ER stress dependent neuronal cell death and protects primary cultured mouse cortical neurons from Aβ1-42 toxicity.4 Increases titers (4 fold) in the production of lentivirus vectors with enhanced efficiency in targeting dendritic cells.5,6
References/Citations:
1) Bischoff et al. (1986), The use of 1-deoxymannojirimycin to evaluated the role of various alpha-mannosidases in oligosaccharide processing in intact cells; J. Biol. Chem., 261 4766
2) Bischoff et al. (1984), The effect of 1-deoxymannojirimycin on rat liver alpha mannosidases.; Biochem. Biophys. Res. Commun., 125 324
3) Fuhrmann et al. (1984), Novel mannosidase inhibitor blocking conversation of high mannose to complex oligosaccharides; Nature, 307 755
4) Miyake and Nagai (2009), Inhibition of alpha-mannosidase attenuates endoplasmic reticulum stress-induced neuronal cell death; Neurotoxicology, 30 144
5) Tai et al. (2011), Production of lentiviral vectors with enhanced efficiency to target dendritic cells by attenuating mannosidase activity of mammalian cells; J. Biol. Eng., 5 1
6) Lee et al. (2012), Construction of stable producer cells to make high-titer lentiviral vectors for dendritic cell-based vaccination; Biotechnol. Bioeng., 109 1551
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