Deucravacitinib | Allosteric TYK2 inhibitor

CAS:
1609392-27-9
Catalog Number:
10-4756
Activity:
Allosteric TYK2 inhibitor
Chemical Names:
6-(Cyclopropanecarbonylamino)-4-[2-methoxy-3-(1-methyl-1,2,4-triazol-3-yl)anilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
Alternate Name:
BMS-986165
Molecular Weight:
425.47
Molecular Formula:
C20H19D3N8O3
Solubility:
Soluble in DMSO (25 mg/ml with warming); ethanol (20 mg/ml)
Physical Properties:
White to off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$100.00
25 mg$375.00
This product is also available in the following library:

Deucravacitinib (1609392-27-9) is very potent and selective allosteric inhibitor of tyrosine kinase 2 (TYK2). It binds to and is selective for the TYK2 pseudokinase domain (JH2, IC50 = 0.2 nM), with no activity against canonical JH1 domain of TYK2, JAK1,2, or 3.1 It is 5-fold less active against the JAK1 JH2 domain (IC50 = 1 nM).  Deucravacitinib blocked signaling and functional responses in human TH17, TH1, B cells, and myeloid cells and displayed robust efficacy in vitro and in vivo in autoimmune disease animal models.2

References/Citations:

  1. Wrobleski et al. (2019), Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165; J. Med. Chem. 62 8973
  2. Burke et al. (2019), Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain; Sci. Transl. Med. 11 eaaw1736
CAS:
1609392-27-9
Catalog Number:
10-4756
Activity:
Allosteric TYK2 inhibitor
Chemical Names:
6-(Cyclopropanecarbonylamino)-4-[2-methoxy-3-(1-methyl-1,2,4-triazol-3-yl)anilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
Alternate Name:
BMS-986165
Molecular Weight:
425.47
Molecular Formula:
C20H19D3N8O3
Solubility:
Soluble in DMSO (25 mg/ml with warming); ethanol (20 mg/ml)
Physical Properties:
White to off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

20% OFF

For Postdoc
Customers!