Size : | Price | Quantity | |
---|---|---|---|
100 mg | $50.00 | ||
500 mg | $150.00 |
Diazoxide (364-98-7) activates ATP-dependent K+ channels1 via inducing translocation of PKC-epsilon from the cytosol to the mitochondria2. Hyperglycemic agent. Induces powerful protective effects against cardiac ischemia via multiple mechanisms.3 Stimulates mitochondrial ATP synthase activity conferring cardioprotection in a streptozotocin-induced acute diabetes model.4 Prevents alterations in memory and synaptic plasticity induced by Amyloid-ß.5
References:
1) Trube et al. (1986), Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells.l; Pflugers Arch., 407 493
2) Kim et al. (2006), Diazoxide acts more as a PKC-epsilon activator, and indirectly activates the mitochondrial K(ATP) channel conferring cardioprotection against hypoxic injury; Br. J. Pharmacol, 149 1059
3) Coetzee (2013), Multiplicity of effectors of the cardioprotective agent, diazoxide; Pharmacol. Ther., 140 167
4) Jasova et al. (2016), Stimulation of mitochondrial ATP synthase activity – a new diazoxide-mediated mechanism of cardioprotection; Physiol. Res., 65 Suppl 1 S119
5) Salgado-Puga et al. (2017), Subclinical Doses of ATP-sensitive Potassium channel Modulators Prevent Alterations in Memory and Synaptic Plasticity Induced by Amyloid-β; J. Alzheimers Dis., 57 205
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Diazoxide (364-98-7) activates ATP-dependent K+ channels1 via inducing translocation of PKC-epsilon from the cytosol to the mitochondria2. Hyperglycemic agent. Induces powerful protective effects against cardiac ischemia via multiple mechanisms.3 Stimulates mitochondrial ATP synthase activity conferring cardioprotection in a streptozotocin-induced acute diabetes model.4 Prevents alterations in memory and synaptic plasticity induced by Amyloid-ß.5
References:
1) Trube et al. (1986), Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells.l; Pflugers Arch., 407 493
2) Kim et al. (2006), Diazoxide acts more as a PKC-epsilon activator, and indirectly activates the mitochondrial K(ATP) channel conferring cardioprotection against hypoxic injury; Br. J. Pharmacol, 149 1059
3) Coetzee (2013), Multiplicity of effectors of the cardioprotective agent, diazoxide; Pharmacol. Ther., 140 167
4) Jasova et al. (2016), Stimulation of mitochondrial ATP synthase activity – a new diazoxide-mediated mechanism of cardioprotection; Physiol. Res., 65 Suppl 1 S119
5) Salgado-Puga et al. (2017), Subclinical Doses of ATP-sensitive Potassium channel Modulators Prevent Alterations in Memory and Synaptic Plasticity Induced by Amyloid-β; J. Alzheimers Dis., 57 205
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